Renoprotective role of the vitamin D receptor in diabetic nephropathy.

@article{citeulike:1801387, abstract = {1,25-Dihydroxyvitamin D3 negatively regulates the renin-angiotensin system (RAS), which plays a critical role in the development of diabetic nephropathy. We tested if mice lacking the vitamin D receptor (VDR) are more susceptible to hyperglycemia-induced renal injury. Diabetic VDR knockout mice developed more severe albuminuria and glomerulosclerosis due to increased glomerular basement membrane thickening and podocyte effacement. More fibronectin (FN) and less nephrin were expressed in the VDR knockout mice compared to diabetic wild-type mice. In receptor knockout mice, increased renin, angiotensinogen, transforming growth factor-beta (TGF-beta), and connective tissue growth factor accompanied the more severe renal injury. 1,25-Dihydroxyvitmain D3 inhibited high glucose (HG)-induced FN production in cultured mesangial cells and increased nephrin expression in cultured podocytes. 1,25-Dihydroxyvitmain D3 also suppressed HG-induced activation of the RAS and TGF-beta in mesangial and juxtaglomerular cells. Our study suggests that receptor-mediated vitamin D actions are renoprotective in diabetic nephropathy.Kidney International advance online publication, 10 October 2007; doi:10.1038/sj.ki.5002572.}, address = {1Division of Biological Sciences, Department of Medicine, The University of Chicago, Chicago, Illinois, USA.}, author = {Zhang, Z and Sun, L and Wang, Y and Ning, G and Minto, A W W. and Kong, J and Quigg, R J J. and Li, Y C C. }, citeulike-article-id = {1801387}, doi = {10.1038/sj.ki.5002572}, issn = {0085-2538}, journal = {Kidney Int}, keywords = {diabetic\_nephropathy, kidney, vit\_d\_knockout}, month = {October}, posted-at = {2008-05-01 13:54:58}, priority = {2}, title = {Renoprotective role of the vitamin D receptor in diabetic nephropathy.}, url = {http://dx.doi.org/10.1038/sj.ki.5002572}, year = {2007} }

TY - JOUR ID - citeulike:1801387 L3 - citeulike-article-id:1801387 TI - Renoprotective role of the vitamin D receptor in diabetic nephropathy. JF - Kidney Int AD - 1Division of Biological Sciences, Department of Medicine, The University of Chicago, Chicago, Illinois, USA. SN - 0085-2538 N2 - 1,25-Dihydroxyvitamin D3 negatively regulates the renin-angiotensin system (RAS), which plays a critical role in the development of diabetic nephropathy. We tested if mice lacking the vitamin D receptor (VDR) are more susceptible to hyperglycemia-induced renal injury. Diabetic VDR knockout mice developed more severe albuminuria and glomerulosclerosis due to increased glomerular basement membrane thickening and podocyte effacement. More fibronectin (FN) and less nephrin were expressed in the VDR knockout mice compared to diabetic wild-type mice. In receptor knockout mice, increased renin, angiotensinogen, transforming growth factor-beta (TGF-beta), and connective tissue growth factor accompanied the more severe renal injury. 1,25-Dihydroxyvitmain D3 inhibited high glucose (HG)-induced FN production in cultured mesangial cells and increased nephrin expression in cultured podocytes. 1,25-Dihydroxyvitmain D3 also suppressed HG-induced activation of the RAS and TGF-beta in mesangial and juxtaglomerular cells. Our study suggests that receptor-mediated vitamin D actions are renoprotective in diabetic nephropathy.Kidney International advance online publication, 10 October 2007; doi:10.1038/sj.ki.5002572. KW - diabetic_nephropathy KW - kidney KW - vit_d_knockout AU - Zhang, Z AU - Sun, L AU - Wang, Y AU - Ning, G AU - Minto, A W AU - Kong, J AU - Quigg, R J AU - Li, Y C PY - 2007/10/10/ UR - http://dx.doi.org/10.1038/sj.ki.5002572 ER -