The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism

@article{citeulike:449092, abstract = {The amygdala is believed to play a key role in assigning emotional significance to specific sensory input, and conditions such as anxiety, autism, stress, and phobias are thought to be linked to its abnormal function. Growing evidence has also implicated the amygdala in mediation of the stress-dampening properties of alcohol. In this issue of the JCI, Pandey and colleagues identify a central amygdaloid signaling pathway involved in anxiety-like and alcohol-drinking behaviors in rats. They report that decreased phosphorylation of cAMP responsive element-binding protein (CREB) resulted in decreased neuropeptide Y (NPY) expression in the central amygdala of alcohol-preferring rats, causing high anxiety-like behavior. Alcohol intake by these animals was shown to increase PKA-dependent CREB phosphorylation and thereby NPY expression, subsequently ameliorating anxiety-like behavior. These provocative data suggest that a CREB-dependent neuromechanism underlies high anxiety-like and excessive alcohol-drinking behavior.}, author = {Wand, Gary }, citeulike-article-id = {449092}, doi = {http://dx.doi.org/10.1172/JCI26436.}, journal = {J. Clin. Invest.}, keywords = {addiction, alcoholism, amygdala, anxiety}, month = {October}, number = {10}, pages = {2697--2699}, posted-at = {2005-12-24 01:12:02}, priority = {3}, title = {The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism}, url = {http://dx.doi.org/10.1172/JCI26436.}, volume = {115}, year = {2005} }

TY - JOUR ID - citeulike:449092 L3 - citeulike-article-id:449092 N2 - The amygdala is believed to play a key role in assigning emotional significance to specific sensory input, and conditions such as anxiety, autism, stress, and phobias are thought to be linked to its abnormal function. Growing evidence has also implicated the amygdala in mediation of the stress-dampening properties of alcohol. In this issue of the JCI, Pandey and colleagues identify a central amygdaloid signaling pathway involved in anxiety-like and alcohol-drinking behaviors in rats. They report that decreased phosphorylation of cAMP responsive element-binding protein (CREB) resulted in decreased neuropeptide Y (NPY) expression in the central amygdala of alcohol-preferring rats, causing high anxiety-like behavior. Alcohol intake by these animals was shown to increase PKA-dependent CREB phosphorylation and thereby NPY expression, subsequently ameliorating anxiety-like behavior. These provocative data suggest that a CREB-dependent neuromechanism underlies high anxiety-like and excessive alcohol-drinking behavior. IS - 10 JF - J. Clin. Invest. EP - 2699 TI - The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism VL - 115 SP - 2697 KW - addiction KW - alcoholism KW - amygdala KW - anxiety AU - Wand, Gary PY - 2005/10/01/ UR - http://dx.doi.org/10.1172/JCI26436. ER -