Neural mechanisms of addiction: the role of reward-related learning and memory.

@article{citeulike:1033555, abstract = {Addiction is a state of compulsive drug use; despite treatment and other attempts to control drug taking, addiction tends to persist. Clinical and laboratory observations have converged on the hypothesis that addiction represents the pathological usurpation of neural processes that normally serve reward-related learning. The major substrates of persistent compulsive drug use are hypothesized to be molecular and cellular mechanisms that underlie long-term associative memories in several forebrain circuits (involving the ventral and dorsal striatum and prefrontal cortex) that receive input from midbrain dopamine neurons. Here we review progress in identifying candidate mechanisms of addiction.}, address = {Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA. seh@harvard.edu}, author = {Hyman, S. E. and Malenka, R. C. and Nestler, E. J. }, citeulike-article-id = {1033555}, doi = {http://dx.doi.org/10.1146/annurev.neuro.29.051605.113009}, issn = {0147-006X}, journal = {Annu Rev Neurosci}, keywords = {addiction, brain, drug, learning, mechanism, memory, opiates, review, reward}, pages = {565--598}, posted-at = {2007-02-02 19:54:45}, priority = {3}, title = {Neural mechanisms of addiction: the role of reward-related learning and memory.}, url = {http://dx.doi.org/10.1146/annurev.neuro.29.051605.113009}, volume = {29}, year = {2006} }

TY - JOUR ID - citeulike:1033555 L3 - citeulike-article-id:1033555 N2 - Addiction is a state of compulsive drug use; despite treatment and other attempts to control drug taking, addiction tends to persist. Clinical and laboratory observations have converged on the hypothesis that addiction represents the pathological usurpation of neural processes that normally serve reward-related learning. The major substrates of persistent compulsive drug use are hypothesized to be molecular and cellular mechanisms that underlie long-term associative memories in several forebrain circuits (involving the ventral and dorsal striatum and prefrontal cortex) that receive input from midbrain dopamine neurons. Here we review progress in identifying candidate mechanisms of addiction. JF - Annu Rev Neurosci SN - 0147-006X AD - Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA. seh@harvard.edu EP - 598 TI - Neural mechanisms of addiction: the role of reward-related learning and memory. VL - 29 SP - 565 KW - addiction KW - brain KW - drug KW - learning KW - mechanism KW - memory KW - opiates KW - review KW - reward AU - Hyman, SE AU - Malenka, RC AU - Nestler, EJ PY - 2006/// UR - http://dx.doi.org/10.1146/annurev.neuro.29.051605.113009 ER -