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xdeupi's drug [27 articles]

当前文献位于 xdeupi's 文献库 标签分类为 drug. You can also see everyone's drug.
  • Physiological relevance of GPCR oligomerization and its impact on drug discovery
    Drug Discovery Today (14 October 2008)
    by R Panetta, M Greenwood
    posted to review pharmacology ligands gpcr drug disease dimer by xdeupi on 2008-10-16 09:57:50 as **
  • Fluorescent GPCR ligands as new tools in pharmacology.
    Current medicinal chemistry, Vol. 15, No. 21. (2008), pp. 2132-2143.
    by K Kuder, K Kieć-Kononowicz
    posted to ligands imaging fluorescence drug binding agonist activation by xdeupi on 2008-10-15 10:30:17 as **
  • Structure of a β1-adrenergic G-protein-coupled receptor
    Nature (25 June 2008)
    by Tony Warne, Maria J Serrano-Vega, Jillian G Baker, Rouslan Moukhametzianov, Patricia C Edwards, Richard Henderson, Andrew GW Leslie, Christopher G Tate, Gebhard FX Schertler
    posted to xray structure ligands drug docking binding b2ar by xdeupi on 2008-09-16 10:15:17 as ** along with 2 people and 2 groups merj TonyIvetac LabCompMed McCammon
  • Clinical consequences of ADR2 polymorphisms
    Pharmacogenomics, Vol. 9, No. 3. (March 2008), pp. 349-358.
    by Hawkins, A Gregory, Weiss, T Scott, Bleecker, R Eugene
    posted to b2ar disease drug genome pharmacology polymorphism review by xdeupi on 2008-05-03 17:12:39 as **
  • Functional assays as prismatic views of drug activity: relevance to new drug discovery.
    Journal of receptor and signal transduction research, Vol. 28, No. 1. (2008), pp. 109-125.
    by T Kenakin
    posted to biased_agonism chemokine drug pharmacology review by xdeupi on 2008-05-03 17:03:08 as **
  • Chemogenomic approaches to rational drug design
    Br J Pharmacol, Vol. 152, No. 1. (29 May 2007), pp. 38-52.
    by D Rognan
    posted to agonist binding drug ligands pharmacology priviledged_structures by xdeupi on 2008-03-28 15:54:47 as ** along with 4 people and 3 groups jmrivort jerome_ucsf_slb jyuh tjimenez LabCompMed G-quadruplex Supramolecular
  • notes Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor.
    J Biol Chem, Vol. 274, No. 31. (30 July 1999), pp. 21867-21872.
    by A Marjamäki, H Frang, M Pihlavisto, AM Hoffrén, T Salminen, MS Johnson, J Kallio, JA Javitch, M Scheinin
    posted to activation binding cys_scanning drug ligands tm5 by xdeupi on 2008-03-07 15:14:37 as ** along with 1 group LabCompMed
  • beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor.
    J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676.
    by MT Drake, JD Violin, EJ Whalen, JW Wisler, SK Shenoy, RJ Lefkowitz
    posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi on 2008-02-27 10:39:07 as *** along with 1 group LabCompMed
  • Smart drug discovery leveraging innovative technologies and predictive knowledge.
    Nat Chem Biol, Vol. 2, No. 12. (December 2006), pp. 646-648.
    by TK Sawyer
    posted to drug pharmacology by xdeupi on 2007-04-23 16:56:56 as ** along with 1 group LabCompMed
  • Chemical Biology & Drug Design: First Anniversary - 2007!
    Chem Biol Drug Des, Vol. 69, No. 1. (January 2007), pp. 1-2.
    by Tomi K K Sawyer
    posted to drug pharmacology review by xdeupi on 2007-04-23 16:56:17 as ** along with 1 group LabCompMed
  • Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
    The EMBO Journal, Vol. aop, No. current. (14 December 2006)
    by Yutong Sun, Jianyun Huang, Yang Xiang, Murat Bastepe, Harald Juppner, Brian K Kobilka, Jillian J Zhang, Xin-Yun Huang
    posted to activation b2ar drug pharmacology switch by xdeupi on 2007-03-21 11:13:23 as ** along with 1 person and 1 group Guff32 LabCompMed
  • Subclassification and nomenclature of alpha- and beta-adrenoceptors.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 129-134.
    by JP Hieble
    posted to agonist b2ar drug genome ligands pharmacology review by xdeupi on 2007-03-12 14:33:19 as ** along with 1 group LabCompMed
  • Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 207-216.
    by JP Hieble
    posted to agonist b2ar drug ligands pharmacology by xdeupi on 2007-03-12 14:32:04 as ** along with 1 group LabCompMed
  • Drugs, their targets and the nature and number of drug targets
    Nature Reviews Drug Discovery, Vol. 5, No. 10., pp. 821-834.
    by Peter Imming, Christian Sinning, Achim Meyer
    posted to review ligands gpcr genome drug by xdeupi on 2007-01-22 17:55:08 as ** along with 4 people and 1 group kuhn massivemayhem Ao_Li2007 yaredo LabCompMed
  • Latest development in drug discovery on G protein-coupled receptors.
    Curr Protein Pept Sci, Vol. 7, No. 5. (October 2006), pp. 465-470.
    by K Lundstrom
    posted to drug gpcr review by xdeupi on 2006-11-04 12:42:42 as ** along with 1 person and 1 group denissohy LabCompMed
  • I want a new drug: G-protein-coupled receptors in drug development.
    Drug Discov Today, Vol. 11, No. 11-12. (June 2006), pp. 481-493.
    by S Schlyer, R Horuk
    posted to drug gpcr ligands pharmacology review by xdeupi on 2006-11-04 12:41:53 as ** along with 1 person and 1 group zimbo1 LabCompMed
  • dummy
    by Dummy
    posted to 5ht1a activation agonist amber amine arrestin b2ar bimane binding cam ccr5 channel chemokine chimera crystallography cterm cxcr1 d250 dimer disease drug dry dynamics ecl2 evolution expression fluorescence folding fret genome gly gpcr gproteins hbond helix helix8 histamine hormone icl3 imaging internalization ionic leukotriene lhr ligands lipids lock loops md membrane modeling mutation n745 n749 nmr no-tag npxxy nterm opioid pharmacology polymorphism pro-kink protonation review rhodopsin s542 sequence ser spin_labeling structure switch test thr thyrotropin tm2 tm3 tm5 tm6 tm7 toggle transmembrane trp txp w648 by xdeupi on 2006-10-30 12:30:16 as ** along with 2 people and 1 group jessicaopacic ivanrt LabCompMed
  • Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor.
    J Comput Aided Mol Des (13 October 2006)
    by Stanley R Krystek, S R Kimura, Andrew J Tebben
    posted to b2ar binding drug ligands modeling pharmacology by xdeupi on 2006-10-27 09:43:03 as ** along with 1 person and 1 group daevans LabCompMed
  • A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.
    Proc Natl Acad Sci U S A, Vol. 103, No. 30. (25 July 2006), pp. 11288-11293.
    by SB Liggett, J Mialet-Perez, S Thaneemit-Chen, SA Weber, SM Greene, D Hodne, B Nelson, J Morrison, MJ Domanski, LE Wagoner, WT Abraham, JL Anderson, JF Carlquist, HJ Krause-Steinrauf, LC Lazzeroni, JD Port, PW Lavori, MR Bristow
    posted to b2ar disease drug genome helix8 ligands polymorphism by xdeupi on 2006-09-05 11:38:25 as ** along with 1 group LabCompMed
  • Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.
    J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125.
    by B Behr, C Hoffmann, G Ottolina, KN Klotz
    posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as *** along with 1 group LabCompMed
  • G proteins in drug screening: from analysis of receptor-G protein specificity to manipulation of GPCR-mediated signalling pathways.
    Curr Pharm Des, Vol. 12, No. 14. (2006), pp. 1703-1715.
    by E Kostenis
    posted to activation cterm drug ecl2 gpcr gproteins pharmacology by xdeupi on 2006-09-05 09:59:05 as **** along with 1 group LabCompMed
  • Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists.
    J Pharmacol Exp Ther (20 July 2006)
    by Terry P P Kenakin, Stephen Jenkinson, Christian Watson
    posted to activation drug ligands agonist pharmacology by xdeupi on 2006-09-05 09:51:58 as **** along with 1 group LabCompMed
  • GPCR agonists and antagonists in the clinic.
    Med Chem, Vol. 1, No. 4. (July 2005), pp. 405-421.
    by JD Tyndall, R Sandilya
    posted to agonist drug gpcr ligands pharmacology by xdeupi on 2006-07-24 10:18:01 as ** along with 1 group LabCompMed
  • Data-Driven Analysis in Drug Discovery
    Journal of Receptors and Signal Transduction, Vol. 26, No. 4. (August 2006), pp. 299-327.
    by Terry Kenakin
    posted to agonist binding drug ligands pharmacology by xdeupi on 2006-07-17 16:28:05 as **** along with 1 group LabCompMed
  • The identification of ligands at orphan G-protein coupled receptors.
    Annu Rev Pharmacol Toxicol, Vol. 44 (2004), pp. 43-66.
    by A Wise, SC Jupe, S Rees
    posted to drug gpcr ligands by xdeupi on 2006-03-01 16:35:26 as ** along with 1 group LabCompMed
  • GPCR antitarget modeling: pharmacophore models for biogenic amine binding GPCRs to avoid GPCR-mediated side effects.
    Chembiochem, Vol. 6, No. 5. (May 2005), pp. 876-889.
    by T Klabunde, A Evers
    posted to amine drug by xdeupi on 2006-01-11 11:25:41 as ** along with 1 group LabCompMed
  • GLIDA: GPCR-ligand database for chemical genomic drug discovery.
    Nucleic Acids Res, Vol. 34, No. Database issue. (1 January 2006)
    by Y Okuno, J Yang, K Taneishi, H Yabuuchi, G Tsujimoto
    posted to drug by xdeupi on 2006-01-11 11:22:31 as ** along with 1 person and 1 group kuhn LabCompMed
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