Intraspecies variation in bacterial genomes: the need for a species genome concept

by: Ruiting Lan, Peter R Reeves

Trends in Microbiology, Vol. 8, No. 9. (1 September 2000), pp. 396-401.

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摘要

Bacterial populations are clonal. Their evolution involves not only divergence between orthologous genes but also gain of genes from other clones or species, which has only recently been widely appreciated through macrorestriction mapping, genomic subtraction and complete genome sequencing. Genes can also be lost in response to selection or by random mutation after becoming redundant. The bacterial genome is a dynamic structure and intraspecies variation needs to be included in genome analysis if we are to gain insight into the full species genome.

@article{citeulike:888789, abstract = {Bacterial populations are clonal. Their evolution involves not only divergence between orthologous genes but also gain of genes from other clones or species, which has only recently been widely appreciated through macrorestriction mapping, genomic subtraction and complete genome sequencing. Genes can also be lost in response to selection or by random mutation after becoming redundant. The bacterial genome is a dynamic structure and intraspecies variation needs to be included in genome analysis if we are to gain insight into the full species genome.}, author = {Lan, Ruiting and Reeves, Peter R. }, citeulike-article-id = {888789}, doi = {http://dx.doi.org/10.1016/S0966-842X(00)01791-1}, journal = {Trends in Microbiology}, keywords = {cgh, gene, islands, lateral, pathogenicity, transfer}, month = {September}, number = {9}, pages = {396--401}, posted-at = {2006-10-08 01:34:43}, priority = {2}, title = {Intraspecies variation in bacterial genomes: the need for a species genome concept}, url = {http://dx.doi.org/10.1016/S0966-842X(00)01791-1}, volume = {8}, year = {2000} }

RIS record

TY - JOUR ID - citeulike:888789 L3 - citeulike-article-id:888789 N2 - Bacterial populations are clonal. Their evolution involves not only divergence between orthologous genes but also gain of genes from other clones or species, which has only recently been widely appreciated through macrorestriction mapping, genomic subtraction and complete genome sequencing. Genes can also be lost in response to selection or by random mutation after becoming redundant. The bacterial genome is a dynamic structure and intraspecies variation needs to be included in genome analysis if we are to gain insight into the full species genome. IS - 9 JF - Trends in Microbiology EP - 401 TI - Intraspecies variation in bacterial genomes: the need for a species genome concept VL - 8 SP - 396 KW - cgh KW - gene KW - islands KW - lateral KW - pathogenicity KW - transfer AU - Lan, Ruiting AU - Reeves, Peter PY - 2000/09/01/ UR - http://dx.doi.org/10.1016/S0966-842X(00)01791-1 ER -

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