HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T Cells

@article{citeulike:3201254, abstract = {Summary Binding of the HIV envelope to the chemokine coreceptors triggers membrane fusion and signal transduction. The fusion process has been well characterized, yet the role of coreceptor signaling remains elusive. Here, we describe a critical function of the chemokine coreceptor signaling in facilitating HIV infection of resting CD4 T cells. We find that static cortical actin in resting T cells represents a restriction and that HIV utilizes the G[alpha]i-dependent signaling from the chemokine coreceptor CXCR4 to activate a cellular actin-depolymerizing factor, cofilin, to overcome this restriction. HIV envelope-mediated cofilin activation and actin dynamics are important for a postentry process that leads to viral nuclear localization. Inhibition of HIV-mediated actin rearrangement markedly diminishes viral latent infection of resting T cells. Conversely, induction of active cofilin greatly facilitates it. These findings shed light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory.}, author = {Yoder, Alyson and Yu, Dongyang and Dong, Li and Iyer, Subashini R. and Xu, Xuehua and Kelly, Jeremy and Liu, Juan and Wang, Weifeng and Vorster, Paul J. and Agulto, Liane and Stephany, David A. and Cooper, James N. and Marsh, Jon W. and Wu, Yuntao }, citeulike-article-id = {3201254}, doi = {http://dx.doi.org/10.1016/j.cell.2008.06.036}, journal = {Cell}, keywords = {entry, hiv}, month = {September}, number = {5}, pages = {782--792}, posted-at = {2008-09-07 18:34:01}, priority = {2}, title = {HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T Cells}, url = {http://dx.doi.org/10.1016/j.cell.2008.06.036}, volume = {134}, year = {2008} }

TY - JOUR ID - citeulike:3201254 L3 - citeulike-article-id:3201254 N2 - Summary Binding of the HIV envelope to the chemokine coreceptors triggers membrane fusion and signal transduction. The fusion process has been well characterized, yet the role of coreceptor signaling remains elusive. Here, we describe a critical function of the chemokine coreceptor signaling in facilitating HIV infection of resting CD4 T cells. We find that static cortical actin in resting T cells represents a restriction and that HIV utilizes the G[alpha]i-dependent signaling from the chemokine coreceptor CXCR4 to activate a cellular actin-depolymerizing factor, cofilin, to overcome this restriction. HIV envelope-mediated cofilin activation and actin dynamics are important for a postentry process that leads to viral nuclear localization. Inhibition of HIV-mediated actin rearrangement markedly diminishes viral latent infection of resting T cells. Conversely, induction of active cofilin greatly facilitates it. These findings shed light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory. IS - 5 JF - Cell EP - 792 TI - HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T Cells VL - 134 SP - 782 KW - entry KW - hiv AU - Yoder, Alyson AU - Yu, Dongyang AU - Dong, Li AU - Iyer, Subashini AU - Xu, Xuehua AU - Kelly, Jeremy AU - Liu, Juan AU - Wang, Weifeng AU - Vorster, Paul AU - Agulto, Liane AU - Stephany, David AU - Cooper, James AU - Marsh, Jon AU - Wu, Yuntao PY - 2008/09/05/ UR - http://dx.doi.org/10.1016/j.cell.2008.06.036 ER -