Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

@article{citeulike:3171991, abstract = {The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease. These cells could in turn be used for disease modeling, drug discovery, and eventually autologous cell replacement therapies. Although recent studies have demonstrated the reprogramming of human fibroblasts to a pluripotent state, it remains unclear whether these induced pluripotent stem (iPS) cells can be produced directly from elderly patients with chronic disease. We have generated iPS cells from an 82-year-old woman diagnosed with a familial form of amyotrophic lateral sclerosis (ALS). These patient-specific iPS cells possess properties of embryonic stem cells and were successfully directed to differentiate into motor neurons, the cell type destroyed in ALS. 10.1126/science.1158799}, author = {Dimos, John T. and Rodolfa, Kit T. and Niakan, Kathy K. and Weisenthal, Laurin M. and Mitsumoto, Hiroshi and Chung, Wendy and Croft, Gist F. and Saphier, Genevieve and Leibel, Rudy and Goland, Robin and Wichterle, Hynek and Henderson, Christopher E. and Eggan, Kevin }, citeulike-article-id = {3171991}, doi = {http://dx.doi.org/10.1126/science.1158799}, journal = {Science}, keywords = {stemcells}, month = {August}, number = {5893}, pages = {1218--1221}, posted-at = {2008-08-29 12:46:24}, priority = {2}, title = {Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons}, url = {http://dx.doi.org/10.1126/science.1158799}, volume = {321}, year = {2008} }

TY - JOUR ID - citeulike:3171991 L3 - citeulike-article-id:3171991 N2 - The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease. These cells could in turn be used for disease modeling, drug discovery, and eventually autologous cell replacement therapies. Although recent studies have demonstrated the reprogramming of human fibroblasts to a pluripotent state, it remains unclear whether these induced pluripotent stem (iPS) cells can be produced directly from elderly patients with chronic disease. We have generated iPS cells from an 82-year-old woman diagnosed with a familial form of amyotrophic lateral sclerosis (ALS). These patient-specific iPS cells possess properties of embryonic stem cells and were successfully directed to differentiate into motor neurons, the cell type destroyed in ALS. 10.1126/science.1158799 IS - 5893 JF - Science EP - 1221 TI - Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons VL - 321 SP - 1218 KW - stemcells AU - Dimos, John AU - Rodolfa, Kit AU - Niakan, Kathy AU - Weisenthal, Laurin AU - Mitsumoto, Hiroshi AU - Chung, Wendy AU - Croft, Gist AU - Saphier, Genevieve AU - Leibel, Rudy AU - Goland, Robin AU - Wichterle, Hynek AU - Henderson, Christopher AU - Eggan, Kevin PY - 2008/08/29/ UR - http://dx.doi.org/10.1126/science.1158799 ER -