Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cells Express the Serotonin Receptor and Are Susceptible to JC Virus Infection

@article{citeulike:3145023, abstract = {We studied the susceptibility of human embryonic stem cell-derived oligodendrocyte progenitor cells to infection with JC virus, the causative agent of progressive multifocal leukoencephalopathy (PML). A human embryonic stem cell line, H7, was used to derive an enriched population of cells expressing the oligodendrocyte progenitor cell-specific marker NG2. These cells expressed the 5HT2a receptor (5HT2aR) for JC virus and were highly susceptible to infection. Infection was reduced by treatment with anti-5HT2aR antibodies and by the 5HT2aR antagonists ritanserin and ketanserin. This is the first demonstration that human embryonic stem cell-derived oligodendrocyte progenitor cells are susceptible to JC virus infection and indicates that cells poised to replenish mature oligodendrocytes in PML lesions may also be a target of viral infection. 10.1128/JVI.00406-08}, author = {Schaumburg, C. and O'Hara, B. A. and Lane, T. E. and Atwood, W. J. }, citeulike-article-id = {3145023}, doi = {http://dx.doi.org/10.1128/JVI.00406-08}, journal = {J. Virol.}, keywords = {stemcells}, month = {September}, number = {17}, pages = {8896--8899}, posted-at = {2008-08-21 14:47:10}, priority = {2}, title = {Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cells Express the Serotonin Receptor and Are Susceptible to JC Virus Infection}, url = {http://dx.doi.org/10.1128/JVI.00406-08}, volume = {82}, year = {2008} }

TY - JOUR ID - citeulike:3145023 L3 - citeulike-article-id:3145023 N2 - We studied the susceptibility of human embryonic stem cell-derived oligodendrocyte progenitor cells to infection with JC virus, the causative agent of progressive multifocal leukoencephalopathy (PML). A human embryonic stem cell line, H7, was used to derive an enriched population of cells expressing the oligodendrocyte progenitor cell-specific marker NG2. These cells expressed the 5HT2a receptor (5HT2aR) for JC virus and were highly susceptible to infection. Infection was reduced by treatment with anti-5HT2aR antibodies and by the 5HT2aR antagonists ritanserin and ketanserin. This is the first demonstration that human embryonic stem cell-derived oligodendrocyte progenitor cells are susceptible to JC virus infection and indicates that cells poised to replenish mature oligodendrocytes in PML lesions may also be a target of viral infection. 10.1128/JVI.00406-08 IS - 17 JF - J. Virol. EP - 8899 TI - Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cells Express the Serotonin Receptor and Are Susceptible to JC Virus Infection VL - 82 SP - 8896 KW - stemcells AU - Schaumburg, C AU - O'Hara, BA AU - Lane, TE AU - Atwood, WJ PY - 2008/09/01/ UR - http://dx.doi.org/10.1128/JVI.00406-08 ER -