Widespread Lateral Gene Transfer from Intracellular Bacteria to Multicellular Eukaryotes

@article{citeulike:1610049, abstract = {Although common among bacteria, lateral gene transferthe movement of genes between distantly related organismsis thought to occur only rarely between bacteria and multicellular eukaryotes. However, the presence of endosymbionts, such as Wolbachia pipientis, within some eukaryotic germlines may facilitate bacterial gene transfers to eukaryotic host genomes. We therefore examined host genomes for evidence of gene transfer events from Wolbachia bacteria to their hosts. We found and confirmed transfers into the genomes of 4 insect and 4 nematode species that range from nearly the entire Wolbachia genome (>1 megabase) to short (<500 base pairs) insertions. Potential Wolbachia to host transfers were also detected computationally in three additional sequenced insect genomes. We also show that some of these inserted Wolbachia genes are transcribed within eukaryotic cells lacking endosymbionts. Therefore, heritable lateral gene transfer occurs into eukaryotic hosts from their prokaryote symbionts, potentially providing a mechanism for acquisition of new genes and functions. 10.1126/science.1142490}, author = {Hotopp, Julie C. and Clark, Michael E. and Oliveira, Deodoro C. and Foster, Jeremy M. and Fischer, Peter and Torres, Monica C. and Giebel, Jonathan D. and Kumar, Nikhil and Ishmael, Nadeeza and Wang, Shiliang and Ingram, Jessica and Nene, Rahul V. and Shepard, Jessica and Tomkins, Jeffrey and Richards, Stephen and Spiro, David J. and Ghedin, Elodie and Slatko, Barton E. and Tettelin, Herve and Werren, John H. }, citeulike-article-id = {1610049}, doi = {http://dx.doi.org/10.1126/science.1142490}, journal = {Science}, keywords = {drosophila, lateral-transfer, wolbachia}, month = {August}, pages = {1142490+}, posted-at = {2007-08-31 01:38:55}, priority = {2}, title = {Widespread Lateral Gene Transfer from Intracellular Bacteria to Multicellular Eukaryotes}, url = {http://dx.doi.org/10.1126/science.1142490}, year = {2007} }

TY - JOUR ID - citeulike:1610049 L3 - citeulike-article-id:1610049 N2 - Although common among bacteria, lateral gene transferthe movement of genes between distantly related organismsis thought to occur only rarely between bacteria and multicellular eukaryotes. However, the presence of endosymbionts, such as Wolbachia pipientis, within some eukaryotic germlines may facilitate bacterial gene transfers to eukaryotic host genomes. We therefore examined host genomes for evidence of gene transfer events from Wolbachia bacteria to their hosts. We found and confirmed transfers into the genomes of 4 insect and 4 nematode species that range from nearly the entire Wolbachia genome (>1 megabase) to short (<500 base pairs) insertions. Potential Wolbachia to host transfers were also detected computationally in three additional sequenced insect genomes. We also show that some of these inserted Wolbachia genes are transcribed within eukaryotic cells lacking endosymbionts. Therefore, heritable lateral gene transfer occurs into eukaryotic hosts from their prokaryote symbionts, potentially providing a mechanism for acquisition of new genes and functions. 10.1126/science.1142490 JF - Science TI - Widespread Lateral Gene Transfer from Intracellular Bacteria to Multicellular Eukaryotes SP - 1142490 KW - drosophila KW - lateral-transfer KW - wolbachia AU - Hotopp, Julie AU - Clark, Michael AU - Oliveira, Deodoro AU - Foster, Jeremy AU - Fischer, Peter AU - Torres, Monica AU - Giebel, Jonathan AU - Kumar, Nikhil AU - Ishmael, Nadeeza AU - Wang, Shiliang AU - Ingram, Jessica AU - Nene, Rahul AU - Shepard, Jessica AU - Tomkins, Jeffrey AU - Richards, Stephen AU - Spiro, David AU - Ghedin, Elodie AU - Slatko, Barton AU - Tettelin, Herve AU - Werren, John PY - 2007/08/30/ UR - http://dx.doi.org/10.1126/science.1142490 ER -