BNArray: an R package for constructing gene regulatory networks from microarray data by using Bayesian network.

by: Xiaohui Chen, Ming Chen, Kaida Ning

Bioinformatics (27 September 2006)

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摘要

SUMMARY: BNArray is a systemized tool developed in R. It facilitates the construction of gene regulatory networks from DNA microarray data by using Bayesian network. Significant submodules of regulatory networks with high confidence are reconstructed by using our extended sub-network mining algorithm of directed graphs. BNArray can handle microarray data sets with missing data. To evaluate the statistical features of generated Bayesian networks, re-sampling procedures are utilized to yield collections of candidate 1st-order network sets for mining dense coherent sub-networks. AVAILABILITY: The R package and the supplementary documentation are available at http://www.cls.zju.edu.cn/binfo/BNArray/.

@article{citeulike:919928, abstract = {SUMMARY: BNArray is a systemized tool developed in R. It facilitates the construction of gene regulatory networks from DNA microarray data by using Bayesian network. Significant submodules of regulatory networks with high confidence are reconstructed by using our extended sub-network mining algorithm of directed graphs. BNArray can handle microarray data sets with missing data. To evaluate the statistical features of generated Bayesian networks, re-sampling procedures are utilized to yield collections of candidate 1st-order network sets for mining dense coherent sub-networks. AVAILABILITY: The R package and the supplementary documentation are available at http://www.cls.zju.edu.cn/binfo/BNArray/.}, address = {Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.}, author = {Chen, Xiaohui and Chen, Ming and Ning, Kaida }, citeulike-article-id = {919928}, issn = {1460-2059}, journal = {Bioinformatics}, keywords = {bayesian, bayesnet, gene, network, r, regulation}, month = {September}, posted-at = {2006-11-18 18:09:29}, priority = {2}, title = {BNArray: an R package for constructing gene regulatory networks from microarray data by using Bayesian network.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17005537}, year = {2006} }

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TY - JOUR ID - citeulike:919928 L3 - citeulike-article-id:919928 N2 - SUMMARY: BNArray is a systemized tool developed in R. It facilitates the construction of gene regulatory networks from DNA microarray data by using Bayesian network. Significant submodules of regulatory networks with high confidence are reconstructed by using our extended sub-network mining algorithm of directed graphs. BNArray can handle microarray data sets with missing data. To evaluate the statistical features of generated Bayesian networks, re-sampling procedures are utilized to yield collections of candidate 1st-order network sets for mining dense coherent sub-networks. AVAILABILITY: The R package and the supplementary documentation are available at http://www.cls.zju.edu.cn/binfo/BNArray/. JF - Bioinformatics SN - 1460-2059 AD - Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China. TI - BNArray: an R package for constructing gene regulatory networks from microarray data by using Bayesian network. KW - bayesian KW - bayesnet KW - gene KW - network KW - r KW - regulation AU - Chen, Xiaohui AU - Chen, Ming AU - Ning, Kaida PY - 2006/09/27/ UR - http://view.ncbi.nlm.nih.gov/pubmed/17005537 ER -

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