Retinal dysfunction in patients with chronic Chagas' disease is associated to anti-Trypanosoma cruzi antibodies that cross-react with rhodopsin.

@article{citeulike:530785, abstract = {To investigate retinal involvement in chronic Chagas' disease, we performed electroretinography and retinal fluorescein angiography studies in chagasic patients. Our results demonstrated a dissociated electrophysiological response characterized by both an abnormal reduction of the electroretinographic b-wave amplitude and a delayed latency, under the dark-adaptated condition. These alterations are compatible with a selective dysfunction of the rods. Antibodies raised against Trypanosoma cruzi that also interact with beta1-adrenergic receptor blocked light stimulation of cGMP-phosphodiesterase in bovine rod membranes. The specificity from the antibody-rhodopsin interaction was confirmed by Western blot analysis and antigenic competition experiments. Our results suggest an immunomediated rhodopsin blockade. T. cruzi infection probably induces an autoimmune response against rhodopsin in the chronic phase of Chagas' disease through a molecular mimicry mechanism similar to that described previously on cardiac human beta1-adrenergic and M2-cholinergic receptors, all related to the same subfamily of G-protein-coupled receptors.}, address = {cpaveto@dna.uba.ar.}, author = {Matsumoto, S. C. and Labovsky, V. and Roncoroni, M. and Guida, M. C. and Gim\'{e}nez, L. and Mitelman, J. and Gori, H. and Jurgelevicius, R. and Grillo, A. and Manfredi, P. and Levin, M. J. and Paveto, C. }, citeulike-article-id = {530785}, doi = {http://dx.doi.org/10.1096/fj.05-4654fje}, issn = {1530-6860}, journal = {FASEB J}, keywords = {cool}, month = {March}, number = {3}, pages = {550--552}, posted-at = {2006-03-04 04:07:46}, priority = {2}, title = {Retinal dysfunction in patients with chronic Chagas' disease is associated to anti-Trypanosoma cruzi antibodies that cross-react with rhodopsin.}, url = {http://dx.doi.org/10.1096/fj.05-4654fje}, volume = {20}, year = {2006} }

TY - JOUR ID - citeulike:530785 L3 - citeulike-article-id:530785 TI - Retinal dysfunction in patients with chronic Chagas' disease is associated to anti-Trypanosoma cruzi antibodies that cross-react with rhodopsin. JF - FASEB J VL - 20 IS - 3 SP - 550 EP - 552 AD - cpaveto@dna.uba.ar. SN - 1530-6860 N2 - To investigate retinal involvement in chronic Chagas' disease, we performed electroretinography and retinal fluorescein angiography studies in chagasic patients. Our results demonstrated a dissociated electrophysiological response characterized by both an abnormal reduction of the electroretinographic b-wave amplitude and a delayed latency, under the dark-adaptated condition. These alterations are compatible with a selective dysfunction of the rods. Antibodies raised against Trypanosoma cruzi that also interact with beta1-adrenergic receptor blocked light stimulation of cGMP-phosphodiesterase in bovine rod membranes. The specificity from the antibody-rhodopsin interaction was confirmed by Western blot analysis and antigenic competition experiments. Our results suggest an immunomediated rhodopsin blockade. T. cruzi infection probably induces an autoimmune response against rhodopsin in the chronic phase of Chagas' disease through a molecular mimicry mechanism similar to that described previously on cardiac human beta1-adrenergic and M2-cholinergic receptors, all related to the same subfamily of G-protein-coupled receptors. KW - cool AU - Matsumoto, SC AU - Labovsky, V AU - Roncoroni, M AU - Guida, MC AU - Giménez, L AU - Mitelman, J AU - Gori, H AU - Jurgelevicius, R AU - Grillo, A AU - Manfredi, P AU - Levin, MJ AU - Paveto, C PY - 2006/03// UR - http://dx.doi.org/10.1096/fj.05-4654fje ER -