Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.

@article{citeulike:917524, abstract = {Serotonin (5-hydroxytryptamine, 5-HT) is, without doubt, the neurotransmitter for which the number of receptors is the highest. Fifteen genes encoding functional 5-HT receptors have been cloned in mammalian brain. 5-HT(3) receptors are ionotropic receptors, whereas all the others are metabotropic G-protein-coupled receptors (GPCRs). 5-HT receptor diversity is further increased by post-genomic modifications, such as alternative splicing (up to 10 splice variants for the 5-HT(4) receptor) or by mRNA editing in the case of 5-HT(2C) receptors. The cellular and behavioral implications of 5-HT(2C) receptor editing are of great physiological importance. Signaling of 5-HT receptors involves a great variety of pathways, but only some of these have been demonstrated in neurons. The classical view of neurotransmitter receptors localized within the synaptic cleft cannot be applied to 5-HT receptors, which are mostly (but not exclusively) localized at extra-synaptic locations either pre- or post-synaptically. 5-HT receptors are engaged in pre- or post-synaptic complexes composed of many GPCR-interacting proteins. The functions of these proteins are starting to be revealed. These proteins have been implicated in targeting, trafficking to or from the membrane, desensitization, and fine-tuning of signaling.}, address = {CNRS, UMR5203, Montpellier, F-34094, France.}, author = {Bockaert, J. and Claeysen, S. and B\'{e}camel, C. and Dumuis, A. and Marin, P. }, citeulike-article-id = {917524}, doi = {http://dx.doi.org/10.1007/s00441-006-0286-1}, issn = {0302-766X}, journal = {Cell Tissue Res}, month = {November}, number = {2}, pages = {553--572}, posted-at = {2008-01-17 01:26:03}, priority = {2}, title = {Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.}, url = {http://dx.doi.org/10.1007/s00441-006-0286-1}, volume = {326}, year = {2006} }

TY - JOUR ID - citeulike:917524 L3 - citeulike-article-id:917524 N2 - Serotonin (5-hydroxytryptamine, 5-HT) is, without doubt, the neurotransmitter for which the number of receptors is the highest. Fifteen genes encoding functional 5-HT receptors have been cloned in mammalian brain. 5-HT(3) receptors are ionotropic receptors, whereas all the others are metabotropic G-protein-coupled receptors (GPCRs). 5-HT receptor diversity is further increased by post-genomic modifications, such as alternative splicing (up to 10 splice variants for the 5-HT(4) receptor) or by mRNA editing in the case of 5-HT(2C) receptors. The cellular and behavioral implications of 5-HT(2C) receptor editing are of great physiological importance. Signaling of 5-HT receptors involves a great variety of pathways, but only some of these have been demonstrated in neurons. The classical view of neurotransmitter receptors localized within the synaptic cleft cannot be applied to 5-HT receptors, which are mostly (but not exclusively) localized at extra-synaptic locations either pre- or post-synaptically. 5-HT receptors are engaged in pre- or post-synaptic complexes composed of many GPCR-interacting proteins. The functions of these proteins are starting to be revealed. These proteins have been implicated in targeting, trafficking to or from the membrane, desensitization, and fine-tuning of signaling. IS - 2 JF - Cell Tissue Res SN - 0302-766X AD - CNRS, UMR5203, Montpellier, F-34094, France. EP - 572 TI - Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation. VL - 326 SP - 553 AU - Bockaert, J AU - Claeysen, S AU - Bécamel, C AU - Dumuis, A AU - Marin, P PY - 2006/11// UR - http://dx.doi.org/10.1007/s00441-006-0286-1 ER -