Regulation of cell cycle re-entry by growth, survival and stress signalling pathways.

by: SJ Cook, K Balmanno, A Garner, T Millar, C Taverner, D Todd

Biochem Soc Trans, Vol. 28, No. 2. (February 2000), pp. 233-240.

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摘要

The mitogen-activated and stress-activated protein kinases transduce signals from plasma membrane signalling machinery into the nucleus to modulate gene expression. By regulating the genomic response to environmental cues (growth factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological responses.

@article{citeulike:789848, abstract = {The mitogen-activated and stress-activated protein kinases transduce signals from plasma membrane signalling machinery into the nucleus to modulate gene expression. By regulating the genomic response to environmental cues (growth factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological responses.}, address = {Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge, UK.}, author = {Cook, S. J. and Balmanno, K. and Garner, A. and Millar, T. and Taverner, C. and Todd, D. }, citeulike-article-id = {789848}, issn = {0300-5127}, journal = {Biochem Soc Trans}, keywords = {cell-cycle}, month = {February}, number = {2}, pages = {233--240}, posted-at = {2008-01-17 01:30:38}, priority = {2}, title = {Regulation of cell cycle re-entry by growth, survival and stress signalling pathways.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10816134}, volume = {28}, year = {2000} }

RIS record

TY - JOUR ID - citeulike:789848 L3 - citeulike-article-id:789848 N2 - The mitogen-activated and stress-activated protein kinases transduce signals from plasma membrane signalling machinery into the nucleus to modulate gene expression. By regulating the genomic response to environmental cues (growth factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological responses. IS - 2 JF - Biochem Soc Trans SN - 0300-5127 AD - Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge, UK. EP - 240 TI - Regulation of cell cycle re-entry by growth, survival and stress signalling pathways. VL - 28 SP - 233 KW - cell-cycle AU - Cook, SJ AU - Balmanno, K AU - Garner, A AU - Millar, T AU - Taverner, C AU - Todd, D PY - 2000/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/10816134 ER -

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