Determination of protein structures - a series of fortunate events

@article{citeulike:2725252, abstract = {Determination of a macromolecular structure using X-ray diffraction is a multi-step process that involves a plethora of techniques involving molecular biology, bioinformatics, and physical sciences. Counterintuitively, the success of any or all individual steps does not guarantee the success of the overall process. This review examines the difficulties presented by each step on the path from a gene to the final publication, together with certain lucky (or unlucky) circumstances that can affect the velocity along that path. 10.1529/biophysj.108.131789}, author = {Chruszcz, Maksymilian and Wlodawer, Alexander and Minor, Wladek }, citeulike-article-id = {2725252}, doi = {http://dx.doi.org/10.1529/biophysj.108.131789}, journal = {Biophys. J.}, keywords = {protein}, month = {April}, pages = {biophysj.108.131789+}, posted-at = {2008-06-28 12:11:49}, priority = {2}, title = {Determination of protein structures - a series of fortunate events}, url = {http://dx.doi.org/10.1529/biophysj.108.131789}, year = {2008} }

TY - JOUR ID - citeulike:2725252 L3 - citeulike-article-id:2725252 N2 - Determination of a macromolecular structure using X-ray diffraction is a multi-step process that involves a plethora of techniques involving molecular biology, bioinformatics, and physical sciences. Counterintuitively, the success of any or all individual steps does not guarantee the success of the overall process. This review examines the difficulties presented by each step on the path from a gene to the final publication, together with certain lucky (or unlucky) circumstances that can affect the velocity along that path. 10.1529/biophysj.108.131789 JF - Biophys. J. TI - Determination of protein structures - a series of fortunate events SP - biophysj.108.131789 KW - protein AU - Chruszcz, Maksymilian AU - Wlodawer, Alexander AU - Minor, Wladek PY - 2008/04/25/ UR - http://dx.doi.org/10.1529/biophysj.108.131789 ER -