The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia.

@article{citeulike:2925700, abstract = {Mice lacking the desmosome protein Perp exhibit blistering in their stratified epithelia and display postnatal lethality. However, it is unclear if these phenotypes are strictly related to Perp function in stratified epithelia, as Perp expression is not restricted to these tissues during embryogenesis, and certain desmosomal blistering diseases such as pemphigus vulgaris and pemphigus foliaceus have non-cell-intrinsic bases. Furthermore, we show here that Perp is expressed in the heart, raising the possibility that defects in heart function could account for lethality in the Perp-deficient mice. To determine conclusively if Perp function in stratified epithelia is crucial for postnatal survival and epithelial adhesion, we specifically ablated Perp in stratified epithelia by breeding conditional Perp knockout mice to keratin 5 (K5)-Cre transgenic mice. We found that the majority of mice lacking Perp in stratified epithelia die within 10 days after birth, accompanied by blistering and hyperproliferation in the epithelia, similar to the constitutive Perp null mice. Together, these findings indicate that Perp's requirement for both viability and epithelial integrity reflects a role in the stratified epithelial compartment.}, address = {Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California 94305, USA.}, author = {Marques, M. R. and Ihrie, R. A. and Horner, J. S. and Attardi, L. D. }, citeulike-article-id = {2925700}, doi = {http://dx.doi.org/10.1038/sj.jid.5700032}, issn = {0022-202X}, journal = {The Journal of investigative dermatology}, keywords = {desmosome, epithelium, p63, perp}, month = {January}, number = {1}, pages = {69--73}, posted-at = {2008-06-25 12:17:33}, priority = {2}, title = {The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia.}, url = {http://dx.doi.org/10.1038/sj.jid.5700032}, volume = {126}, year = {2006} }

TY - JOUR ID - citeulike:2925700 L3 - citeulike-article-id:2925700 N2 - Mice lacking the desmosome protein Perp exhibit blistering in their stratified epithelia and display postnatal lethality. However, it is unclear if these phenotypes are strictly related to Perp function in stratified epithelia, as Perp expression is not restricted to these tissues during embryogenesis, and certain desmosomal blistering diseases such as pemphigus vulgaris and pemphigus foliaceus have non-cell-intrinsic bases. Furthermore, we show here that Perp is expressed in the heart, raising the possibility that defects in heart function could account for lethality in the Perp-deficient mice. To determine conclusively if Perp function in stratified epithelia is crucial for postnatal survival and epithelial adhesion, we specifically ablated Perp in stratified epithelia by breeding conditional Perp knockout mice to keratin 5 (K5)-Cre transgenic mice. We found that the majority of mice lacking Perp in stratified epithelia die within 10 days after birth, accompanied by blistering and hyperproliferation in the epithelia, similar to the constitutive Perp null mice. Together, these findings indicate that Perp's requirement for both viability and epithelial integrity reflects a role in the stratified epithelial compartment. IS - 1 JF - The Journal of investigative dermatology SN - 0022-202X AD - Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California 94305, USA. EP - 73 TI - The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia. VL - 126 SP - 69 KW - desmosome KW - epithelium KW - p63 KW - perp AU - Marques, MR AU - Ihrie, RA AU - Horner, JS AU - Attardi, LD PY - 2006/01// UR - http://dx.doi.org/10.1038/sj.jid.5700032 ER -