Glycosylation of glycolipids in the Golgi complex

by: Hugo JF Maccioni

Journal of Neurochemistry, Vol. 103, No. s1. (2007), pp. 81-90.

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glycosylation, golgi

摘要

Abstract Gangliosides are a family of glycolipids characterized by containing a variable number of sialic acid residues. Nearly, all animal cells contain at least some class of ganglioside in their membranes, but membranes from the CNS are characterized by their high content of these lipids. The synthesis of the oligosaccharide moiety of glycolipids is carried out in the Golgi complex. In this study, I will discuss the cellular and molecular basis of the organization of the glycosylating machinery in the Golgi complex, with particular attention to the mutual relationships, sub-Golgi localization, and intracellular trafficking of glycolipid glycosyltransferases, and to their relationships with the corresponding glycolipid acceptors and sugar nucleotide donors. I will also discuss how the organization of the glycosylating machinery in the Golgi may adapt to events controlling glycolipid expression.

@article{citeulike:2156919, abstract = {Abstract Gangliosides are a family of glycolipids characterized by containing a variable number of sialic acid residues. Nearly, all animal cells contain at least some class of ganglioside in their membranes, but membranes from the CNS are characterized by their high content of these lipids. The synthesis of the oligosaccharide moiety of glycolipids is carried out in the Golgi complex. In this study, I will discuss the cellular and molecular basis of the organization of the glycosylating machinery in the Golgi complex, with particular attention to the mutual relationships, sub-Golgi localization, and intracellular trafficking of glycolipid glycosyltransferases, and to their relationships with the corresponding glycolipid acceptors and sugar nucleotide donors. I will also discuss how the organization of the glycosylating machinery in the Golgi may adapt to events controlling glycolipid expression.}, author = {Maccioni, Hugo J. F. }, citeulike-article-id = {2156919}, doi = {http://dx.doi.org/10.1111/j.1471-4159.2007.04717.x}, journal = {Journal of Neurochemistry}, keywords = {glycosylation, golgi}, number = {s1}, pages = {81--90}, posted-at = {2007-12-21 20:42:38}, priority = {2}, title = {Glycosylation of glycolipids in the Golgi complex}, url = {http://dx.doi.org/10.1111/j.1471-4159.2007.04717.x}, volume = {103}, year = {2007} }

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TY - JOUR ID - citeulike:2156919 L3 - citeulike-article-id:2156919 N2 - Abstract Gangliosides are a family of glycolipids characterized by containing a variable number of sialic acid residues. Nearly, all animal cells contain at least some class of ganglioside in their membranes, but membranes from the CNS are characterized by their high content of these lipids. The synthesis of the oligosaccharide moiety of glycolipids is carried out in the Golgi complex. In this study, I will discuss the cellular and molecular basis of the organization of the glycosylating machinery in the Golgi complex, with particular attention to the mutual relationships, sub-Golgi localization, and intracellular trafficking of glycolipid glycosyltransferases, and to their relationships with the corresponding glycolipid acceptors and sugar nucleotide donors. I will also discuss how the organization of the glycosylating machinery in the Golgi may adapt to events controlling glycolipid expression. IS - s1 JF - Journal of Neurochemistry EP - 90 TI - Glycosylation of glycolipids in the Golgi complex VL - 103 SP - 81 KW - glycosylation KW - golgi AU - Maccioni, Hugo PY - 2007/// UR - http://dx.doi.org/10.1111/j.1471-4159.2007.04717.x ER -

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