Stochastically curtailed tests in long–term clinical trials

by: Gordon KK Lan, Richard Simon, Max Halperin

Sequential Analysis, Vol. 1, No. 3. (1982), pp. 207-219.

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摘要

In data monitoring of long-term clinical trials one frequently faces the question of whether the trial should be terminated early either to reject or "accept" the null hypothesis (H0). To help answer this question, this paper suggests that, in the context of a particular proposed analysis at the end of the trial, one might stop early and reject (accept) H0 when the Conditional probability under H0 (the alternative hypothesis, Ha)

@article{citeulike:2473121, abstract = {In data monitoring of long-term clinical trials one frequently faces the question of whether the trial should be terminated early either to reject or "accept" the null hypothesis (H0). To help answer this question, this paper suggests that, in the context of a particular proposed analysis at the end of the trial, one might stop early and reject (accept) H0 when the Conditional probability under H0 (the alternative hypothesis, Ha)}, author = {Lan, Gordon K. K. and Simon, Richard and Halperin, Max }, citeulike-article-id = {2473121}, doi = {http://dx.doi.org/10.1080/07474948208836014}, journal = {Sequential Analysis}, keywords = {clinical\_trial, sequential, stochastic\_curtailment}, number = {3}, pages = {207--219}, posted-at = {2008-03-05 14:10:28}, priority = {2}, publisher = {Taylor \& Francis}, title = {Stochastically curtailed tests in long\–term clinical trials}, url = {http://dx.doi.org/10.1080/07474948208836014}, volume = {1}, year = {1982} }

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TY - JOUR ID - citeulike:2473121 L3 - citeulike-article-id:2473121 N2 - In data monitoring of long-term clinical trials one frequently faces the question of whether the trial should be terminated early either to reject or "accept" the null hypothesis (H0). To help answer this question, this paper suggests that, in the context of a particular proposed analysis at the end of the trial, one might stop early and reject (accept) H0 when the Conditional probability under H0 (the alternative hypothesis, Ha) IS - 3 JF - Sequential Analysis EP - 219 TI - Stochastically curtailed tests in long–term clinical trials PB - Taylor & Francis VL - 1 SP - 207 KW - clinical_trial KW - sequential KW - stochastic_curtailment AU - Lan, Gordon AU - Simon, Richard AU - Halperin, Max PY - 1982/// UR - http://dx.doi.org/10.1080/07474948208836014 ER -

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