The Fibronectin-Binding Proteins of Staphylococcus aureus May Promote Mammary Gland Colonization in a Lactating Mouse Model of Mastitis

by: Eric Brouillette, Brian G Talbot, Francois Malouin

Infect. Immun., Vol. 71, No. 4. (1 April 2003), pp. 2292-2295.

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摘要

The fibronectin-binding proteins (FnBPs) of Staphylococcus aureus are believed to be implicated in the pathogen's adherence to and colonization of bovine mammary glands, thus leading to infectious mastitis. In vitro studies have shown that FnBPs help the adhesion of the pathogen to bovine mammary epithelial cells. However, the importance of FnBPs for the infection of mammary glands has never been directly established in vivo. In this study with a mouse model of mastitis, the presence of FnBPs on the surface of S. aureus increased the capacity of the bacterium to colonize mammary glands under suckling pressure compared to that of a mutant lacking FnBPs. 10.1128/IAI.71.4.2292-2295.2003

@article{citeulike:3130586, abstract = {The fibronectin-binding proteins (FnBPs) of Staphylococcus aureus are believed to be implicated in the pathogen's adherence to and colonization of bovine mammary glands, thus leading to infectious mastitis. In vitro studies have shown that FnBPs help the adhesion of the pathogen to bovine mammary epithelial cells. However, the importance of FnBPs for the infection of mammary glands has never been directly established in vivo. In this study with a mouse model of mastitis, the presence of FnBPs on the surface of S. aureus increased the capacity of the bacterium to colonize mammary glands under suckling pressure compared to that of a mutant lacking FnBPs. 10.1128/IAI.71.4.2292-2295.2003}, author = {Brouillette, Eric and Talbot, Brian G. and Malouin, Francois }, citeulike-article-id = {3130586}, doi = {http://dx.doi.org/10.1128/IAI.71.4.2292-2295.2003}, journal = {Infect. Immun.}, keywords = {internalization, invasion, mastitis, saureus}, month = {April}, number = {4}, pages = {2292--2295}, posted-at = {2008-08-17 23:35:19}, priority = {2}, title = {The Fibronectin-Binding Proteins of Staphylococcus aureus May Promote Mammary Gland Colonization in a Lactating Mouse Model of Mastitis}, url = {http://dx.doi.org/10.1128/IAI.71.4.2292-2295.2003}, volume = {71}, year = {2003} }

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TY - JOUR ID - citeulike:3130586 L3 - citeulike-article-id:3130586 N2 - The fibronectin-binding proteins (FnBPs) of Staphylococcus aureus are believed to be implicated in the pathogen's adherence to and colonization of bovine mammary glands, thus leading to infectious mastitis. In vitro studies have shown that FnBPs help the adhesion of the pathogen to bovine mammary epithelial cells. However, the importance of FnBPs for the infection of mammary glands has never been directly established in vivo. In this study with a mouse model of mastitis, the presence of FnBPs on the surface of S. aureus increased the capacity of the bacterium to colonize mammary glands under suckling pressure compared to that of a mutant lacking FnBPs. 10.1128/IAI.71.4.2292-2295.2003 IS - 4 JF - Infect. Immun. EP - 2295 TI - The Fibronectin-Binding Proteins of Staphylococcus aureus May Promote Mammary Gland Colonization in a Lactating Mouse Model of Mastitis VL - 71 SP - 2292 KW - internalization KW - invasion KW - mastitis KW - saureus AU - Brouillette, Eric AU - Talbot, Brian AU - Malouin, Francois PY - 2003/04/01/ UR - http://dx.doi.org/10.1128/IAI.71.4.2292-2295.2003 ER -

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