Temporal and Spatial Regulation of Chemotaxis

by: Miho Iijima, Yi E Huang, Peter Devreotes

Developmental Cell, Vol. 3, No. 4. (October 2002), pp. 469-478.

View FullText article

DOI, ScienceDirect

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

vladimirov

Find related articles with these CiteULike tags

chemotaxis, eukaryotic, review

摘要

The ability to sense and respond to shallow gradients of extracellular signals is remarkably similar in Dictyostelium discoideum amoebae and mammalian leukocytes. Chemoattractant receptors and G proteins are fairly evenly distributed along the cell surface. Receptor occupancy generates local excitatory and global inhibitory processes that balance to control the chemotactic response. Uniform stimuli transiently recruit PI3Ks to, and release PTEN from, the plasma membrane, while gradients of chemoattractant cause the two enzymes to bind to the membrane at the front and back of the cell, respectively. Interference with PI3Ks alters chemotaxis, and disruption of PTEN broadens PI localization and actin polymerization in parallel. Thus, counteracting signals from the upstream elements of the pathway converge to regulate the key enzymes of PI metabolism, localize these lipids, and direct pseudopod formation.

@article{2002Iijima, abstract = {The ability to sense and respond to shallow gradients of extracellular signals is remarkably similar in Dictyostelium discoideum amoebae and mammalian leukocytes. Chemoattractant receptors and G proteins are fairly evenly distributed along the cell surface. Receptor occupancy generates local excitatory and global inhibitory processes that balance to control the chemotactic response. Uniform stimuli transiently recruit PI3Ks to, and release PTEN from, the plasma membrane, while gradients of chemoattractant cause the two enzymes to bind to the membrane at the front and back of the cell, respectively. Interference with PI3Ks alters chemotaxis, and disruption of PTEN broadens PI localization and actin polymerization in parallel. Thus, counteracting signals from the upstream elements of the pathway converge to regulate the key enzymes of PI metabolism, localize these lipids, and direct pseudopod formation.}, author = {Iijima, Miho and Huang, Yi E. and Devreotes, Peter }, citeulike-article-id = {3095882}, doi = {http://dx.doi.org/10.1016/S1534-5807(02)00292-7}, journal = {Developmental Cell}, keywords = {chemotaxis, eukaryotic, review}, month = {October}, number = {4}, pages = {469--478}, posted-at = {2008-08-07 14:12:59}, priority = {2}, title = {Temporal and Spatial Regulation of Chemotaxis}, url = {http://dx.doi.org/10.1016/S1534-5807(02)00292-7}, volume = {3}, year = {2002} }

RIS record

TY - JOUR ID - 2002Iijima L3 - citeulike-article-id:3095882 N2 - The ability to sense and respond to shallow gradients of extracellular signals is remarkably similar in Dictyostelium discoideum amoebae and mammalian leukocytes. Chemoattractant receptors and G proteins are fairly evenly distributed along the cell surface. Receptor occupancy generates local excitatory and global inhibitory processes that balance to control the chemotactic response. Uniform stimuli transiently recruit PI3Ks to, and release PTEN from, the plasma membrane, while gradients of chemoattractant cause the two enzymes to bind to the membrane at the front and back of the cell, respectively. Interference with PI3Ks alters chemotaxis, and disruption of PTEN broadens PI localization and actin polymerization in parallel. Thus, counteracting signals from the upstream elements of the pathway converge to regulate the key enzymes of PI metabolism, localize these lipids, and direct pseudopod formation. IS - 4 JF - Developmental Cell EP - 478 TI - Temporal and Spatial Regulation of Chemotaxis VL - 3 SP - 469 KW - chemotaxis KW - eukaryotic KW - review AU - Iijima, Miho AU - Huang, Yi AU - Devreotes, Peter PY - 2002/10// UR - http://dx.doi.org/10.1016/S1534-5807(02)00292-7 ER -

RIS BibTeX