Adolescence: Vulnerable Period for Stress-Induced Prefrontal Cortical Function? Introduction to Part IV

by: Amy F Arnsten, Rebecca M Shansky

Annals of the New York Academy of Sciences, Vol. 1021, No. 1. (2004), pp. 143-147.

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摘要

Exposure to even mild uncontrollable stress impairs the cognitive functioning of the prefrontal cortex, a brain region critical for insight, judgment, and the inhibition of inappropriate behaviors. Several neurobiological factors may contribute to an exaggeration of the stress response in adolescence, for example, an increased dopaminergic projection to prefrontal cortex, and in females, increased circulating estrogen, as estrogen amplifies many aspects of the stress response and lowers the threshold for stress-induced prefrontal cortical dysfunction. These neurobiological factors may increase susceptibility to impaired judgment, drug addiction, and neuropsychiatric disorders during adolescence.

@article{citeulike:1463737, abstract = {Exposure to even mild uncontrollable stress impairs the cognitive functioning of the prefrontal cortex, a brain region critical for insight, judgment, and the inhibition of inappropriate behaviors. Several neurobiological factors may contribute to an exaggeration of the stress response in adolescence, for example, an increased dopaminergic projection to prefrontal cortex, and in females, increased circulating estrogen, as estrogen amplifies many aspects of the stress response and lowers the threshold for stress-induced prefrontal cortical dysfunction. These neurobiological factors may increase susceptibility to impaired judgment, drug addiction, and neuropsychiatric disorders during adolescence.}, author = {Arnsten, Amy F. and Shansky, Rebecca M. }, citeulike-article-id = {1463737}, doi = {http://dx.doi.org/10.1196/annals.1308.017}, journal = {Annals of the New York Academy of Sciences}, keywords = {adolescence, adolescent, depression}, number = {1}, pages = {143--147}, posted-at = {2007-07-17 22:12:18}, priority = {2}, title = {Adolescence: Vulnerable Period for Stress-Induced Prefrontal Cortical Function? Introduction to Part IV}, url = {http://dx.doi.org/10.1196/annals.1308.017}, volume = {1021}, year = {2004} }

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TY - JOUR ID - citeulike:1463737 L3 - citeulike-article-id:1463737 N2 - Exposure to even mild uncontrollable stress impairs the cognitive functioning of the prefrontal cortex, a brain region critical for insight, judgment, and the inhibition of inappropriate behaviors. Several neurobiological factors may contribute to an exaggeration of the stress response in adolescence, for example, an increased dopaminergic projection to prefrontal cortex, and in females, increased circulating estrogen, as estrogen amplifies many aspects of the stress response and lowers the threshold for stress-induced prefrontal cortical dysfunction. These neurobiological factors may increase susceptibility to impaired judgment, drug addiction, and neuropsychiatric disorders during adolescence. IS - 1 JF - Annals of the New York Academy of Sciences EP - 147 TI - Adolescence: Vulnerable Period for Stress-Induced Prefrontal Cortical Function? Introduction to Part IV VL - 1021 SP - 143 KW - adolescence KW - adolescent KW - depression AU - Arnsten, Amy AU - Shansky, Rebecca PY - 2004/// UR - http://dx.doi.org/10.1196/annals.1308.017 ER -

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