High-Speed Imaging Reveals Neurophysiological Links to Behavior in an Animal Model of Depression

@article{citeulike:1439666, abstract = {The hippocampus is one of several brain areas thought to play a central role in affective behaviors, but the underlying local network dynamics are not understood. We used quantitative voltage-sensitive dye imaging to probe hippocampal dynamics with millisecond resolution in brain slices following bidirectional modulation of affective state in rodent models of depression. We found that a simple measure of real-time activity, stimulus-evoked percolation of activity through the dentate gyrus relative to the hippocampal output subfield, accounted for induced changes in animal behavior independent of the underlying mechanism of action of the treatments. Our results define a network-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms. 10.1126/science.1144400}, author = {Airan, Raag D. and Meltzer, Leslie A. and Roy, Madhuri and Roy, Madhuri and Gong, Yuqing and Chen, Han and Deisseroth, Karl }, citeulike-article-id = {1439666}, doi = {http://dx.doi.org/10.1126/science.1144400}, journal = {Science}, keywords = {animal, depression, model}, month = {July}, pages = {1144400+}, posted-at = {2007-07-09 10:07:52}, priority = {2}, title = {High-Speed Imaging Reveals Neurophysiological Links to Behavior in an Animal Model of Depression}, url = {http://dx.doi.org/10.1126/science.1144400}, year = {2007} }

TY - JOUR ID - citeulike:1439666 L3 - citeulike-article-id:1439666 N2 - The hippocampus is one of several brain areas thought to play a central role in affective behaviors, but the underlying local network dynamics are not understood. We used quantitative voltage-sensitive dye imaging to probe hippocampal dynamics with millisecond resolution in brain slices following bidirectional modulation of affective state in rodent models of depression. We found that a simple measure of real-time activity, stimulus-evoked percolation of activity through the dentate gyrus relative to the hippocampal output subfield, accounted for induced changes in animal behavior independent of the underlying mechanism of action of the treatments. Our results define a network-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms. 10.1126/science.1144400 JF - Science TI - High-Speed Imaging Reveals Neurophysiological Links to Behavior in an Animal Model of Depression SP - 1144400 KW - animal KW - depression KW - model AU - Airan, Raag AU - Meltzer, Leslie AU - Roy, Madhuri AU - Roy, Madhuri AU - Gong, Yuqing AU - Chen, Han AU - Deisseroth, Karl PY - 2007/07/05/ UR - http://dx.doi.org/10.1126/science.1144400 ER -