Novel regulatory interactions and activities of mammalian tRNA synthetases.

@article{citeulike:976106, abstract = {Aminoacyl-tRNA synthetases (ARSs) catalyze the attachment of specific amino acids to their cognate tRNAs, thereby ensuring the faithful translation of genetic code. In addition to their enzymatic function, these enzymes have been discovered to regulate various cellular functions such as tRNA export, ribosomal RNA synthesis, apoptosis, inflammation and angiogenesis in mammalian. The insights into the noncanonical activities of these enzymes have been obtained from their unique cellular localization, interacting partners, isoform generation and expression control. Mammalian ARSs also form a macromolecular protein complex with a few auxiliary factors. Although the physiological significance of this complex is poorly understood, it also supports the potential of mammalian ARSs as sophisticated multifunctional proteins for regulating various cellular procedures. In this review, the novel regulatory activities of mammalian ARSs will be discussed in different biological processes.}, address = {National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, Korea.}, author = {Ko, Y. G. and Park, H. and Kim, S. }, citeulike-article-id = {976106}, doi = {10.1002/1615-9861(200209)2:9<1304::AID-PROT1304>3.0.CO;2-E}, issn = {1615-9853}, journal = {Proteomics}, keywords = {enzyme\_and\_transcription\_factor}, month = {September}, number = {9}, pages = {1304--1310}, posted-at = {2006-12-06 11:34:26}, priority = {2}, title = {Novel regulatory interactions and activities of mammalian tRNA synthetases.}, url = {http://dx.doi.org/10.1002/1615-9861(200209)2:9\%3C1304::AID-PROT1304\%3E3.0.CO;2-E}, volume = {2}, year = {2002} }

TY - JOUR ID - citeulike:976106 L3 - citeulike-article-id:976106 TI - Novel regulatory interactions and activities of mammalian tRNA synthetases. JF - Proteomics VL - 2 IS - 9 SP - 1304 EP - 1310 AD - National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, Korea. SN - 1615-9853 N2 - Aminoacyl-tRNA synthetases (ARSs) catalyze the attachment of specific amino acids to their cognate tRNAs, thereby ensuring the faithful translation of genetic code. In addition to their enzymatic function, these enzymes have been discovered to regulate various cellular functions such as tRNA export, ribosomal RNA synthesis, apoptosis, inflammation and angiogenesis in mammalian. The insights into the noncanonical activities of these enzymes have been obtained from their unique cellular localization, interacting partners, isoform generation and expression control. Mammalian ARSs also form a macromolecular protein complex with a few auxiliary factors. Although the physiological significance of this complex is poorly understood, it also supports the potential of mammalian ARSs as sophisticated multifunctional proteins for regulating various cellular procedures. In this review, the novel regulatory activities of mammalian ARSs will be discussed in different biological processes. KW - enzyme_and_transcription_factor AU - Ko, YG AU - Park, H AU - Kim, S PY - 2002/09// UR - http://dx.doi.org/10.1002/1615-9861(200209)2:9%3C1304::AID-PROT1304%3E3.0.CO;2-E ER -