Dissecting protein-protein recognition sites

@article{citeulike:161153, abstract = {The recognition sites in 70 pairwise protein-protein complexes of known three-dimensional structure are dissected in a set of surface patches by clustering atoms at the interface. When the interface buries <2000 A2 of protein surface, the recognition sites usually form a single patch on the surface of each component protein. In contrast, larger interfaces are generally multipatch, with at least one pair of patches that are equivalent in size to a single-patch interface. Each recognition site, or patch within a site, contains a core made of buried interface atoms, surrounded by a rim of atoms that remain accessible to solvent in the complex. A simple geometric model reproduces the number and distribution of atoms within a patch. The rim is similar in composition to the rest of the protein surface, but the core has a distinctive amino acid composition, which may help in identifying potential protein recognition sites on single proteins of known structures. Copyright 2002 Wiley-Liss, Inc. [Journal Article; In English; United States]}, author = {Chakrabarti, Pinak and Janin, Joel }, citeulike-article-id = {161153}, journal = {Proteins}, month = {May}, number = {3}, pages = {334--343}, posted-at = {2007-09-11 14:57:46}, priority = {0}, title = {Dissecting protein-protein recognition sites}, url = {http://www.sciencedirect.com/science/article/B6WVB-45N42H7-324/2/1dbea1a08128f645104c581c3923b7dd}, volume = {47}, year = {2002} }

TY - JOUR ID - citeulike:161153 L3 - citeulike-article-id:161153 TI - Dissecting protein-protein recognition sites JF - Proteins VL - 47 IS - 3 SP - 334 EP - 343 N2 - The recognition sites in 70 pairwise protein-protein complexes of known three-dimensional structure are dissected in a set of surface patches by clustering atoms at the interface. When the interface buries <2000 A2 of protein surface, the recognition sites usually form a single patch on the surface of each component protein. In contrast, larger interfaces are generally multipatch, with at least one pair of patches that are equivalent in size to a single-patch interface. Each recognition site, or patch within a site, contains a core made of buried interface atoms, surrounded by a rim of atoms that remain accessible to solvent in the complex. A simple geometric model reproduces the number and distribution of atoms within a patch. The rim is similar in composition to the rest of the protein surface, but the core has a distinctive amino acid composition, which may help in identifying potential protein recognition sites on single proteins of known structures. Copyright 2002 Wiley-Liss, Inc. [Journal Article; In English; United States] AU - Chakrabarti, Pinak AU - Janin, Joel PY - 2002/05/15/ UR - http://www.sciencedirect.com/science/article/B6WVB-45N42H7-324/2/1dbea1a08128f645104c581c3923b7dd ER -