Protein networks in disease

by: Trey Ideker, Roded Sharan

Genome Res., Vol. 18, No. 4. (1 April 2008), pp. 644-652.

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摘要

During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to perturbation, and for assignment of new protein functions. Following these analyses, and with the recent rise of protein interaction measurements in mammals, protein networks are increasingly serving as tools to unravel the molecular basis of disease. We review promising applications of protein networks to disease in four major areas: identifying new disease genes; the study of their network properties; identifying disease-related subnetworks; and network-based disease classification. Applications in infectious disease, personalized medicine, and pharmacology are also forthcoming as the available protein network information improves in quality and coverage. 10.1101/gr.071852.107

@article{citeulike:2620752, abstract = {During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to perturbation, and for assignment of new protein functions. Following these analyses, and with the recent rise of protein interaction measurements in mammals, protein networks are increasingly serving as tools to unravel the molecular basis of disease. We review promising applications of protein networks to disease in four major areas: identifying new disease genes; the study of their network properties; identifying disease-related subnetworks; and network-based disease classification. Applications in infectious disease, personalized medicine, and pharmacology are also forthcoming as the available protein network information improves in quality and coverage. 10.1101/gr.071852.107}, author = {Ideker, Trey and Sharan, Roded }, citeulike-article-id = {2620752}, doi = {10.1101/gr.071852.107}, journal = {Genome Res.}, month = {April}, number = {4}, pages = {644--652}, posted-at = {2008-04-28 06:38:25}, priority = {0}, title = {Protein networks in disease}, url = {http://dx.doi.org/10.1101/gr.071852.107}, volume = {18}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2620752 L3 - citeulike-article-id:2620752 TI - Protein networks in disease JF - Genome Res. VL - 18 IS - 4 SP - 644 EP - 652 N2 - During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to perturbation, and for assignment of new protein functions. Following these analyses, and with the recent rise of protein interaction measurements in mammals, protein networks are increasingly serving as tools to unravel the molecular basis of disease. We review promising applications of protein networks to disease in four major areas: identifying new disease genes; the study of their network properties; identifying disease-related subnetworks; and network-based disease classification. Applications in infectious disease, personalized medicine, and pharmacology are also forthcoming as the available protein network information improves in quality and coverage. 10.1101/gr.071852.107 AU - Ideker, Trey AU - Sharan, Roded PY - 2008/04/01/ UR - http://dx.doi.org/10.1101/gr.071852.107 ER -

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