Functions of dopamine in the dorsal and ventral striatum

by: Trevor W Robbins, Barry J Everitt

Seminars in Neuroscience, Vol. 4, No. 2. (April 1992), pp. 119-127.

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摘要

Manipulations of dopamine levels in the dorsal and ventral striatum are shown to affect the activation of behaviour in distinct, yet parallel ways, which depend upon the nature of the neocortical and limbic input to these structures. Whereas dopamine in the dorsal striatum contributes to the sensorimotor co-ordination of consummatory behaviour and the development of a `response set' in motor preparatory processes for skilled responses, dopamine in the ventral striatum influences the impact of reward-related stimuli on appetitive aspects of behaviour. The circumstances under which the striatal dopamine projections are normally active to effect these functions are defined by studies which attempt to correlate firing in single units or neurochemical indices of dopamine activity with environmental conditions, internal states and behaviour.

@article{citeulike:1806523, abstract = {Manipulations of dopamine levels in the dorsal and ventral striatum are shown to affect the activation of behaviour in distinct, yet parallel ways, which depend upon the nature of the neocortical and limbic input to these structures. Whereas dopamine in the dorsal striatum contributes to the sensorimotor co-ordination of consummatory behaviour and the development of a `response set' in motor preparatory processes for skilled responses, dopamine in the ventral striatum influences the impact of reward-related stimuli on appetitive aspects of behaviour. The circumstances under which the striatal dopamine projections are normally active to effect these functions are defined by studies which attempt to correlate firing in single units or neurochemical indices of dopamine activity with environmental conditions, internal states and behaviour.}, author = {Robbins, Trevor W. and Everitt, Barry J. }, booktitle = {Milestones in Dopamine Research}, citeulike-article-id = {1806523}, doi = {10.1016/1044-5765(92)90010-Y}, journal = {Seminars in Neuroscience}, keywords = {dopamine, dorsal\_striatum, striatum, ventral\_striatum}, month = {April}, number = {2}, pages = {119--127}, posted-at = {2007-10-22 15:03:01}, priority = {2}, title = {Functions of dopamine in the dorsal and ventral striatum}, url = {http://dx.doi.org/10.1016/1044-5765(92)90010-Y}, volume = {4}, year = {1992} }

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TY - JOUR ID - citeulike:1806523 L3 - citeulike-article-id:1806523 TI - Functions of dopamine in the dorsal and ventral striatum T2 - Milestones in Dopamine Research JF - Seminars in Neuroscience VL - 4 IS - 2 SP - 119 EP - 127 N2 - Manipulations of dopamine levels in the dorsal and ventral striatum are shown to affect the activation of behaviour in distinct, yet parallel ways, which depend upon the nature of the neocortical and limbic input to these structures. Whereas dopamine in the dorsal striatum contributes to the sensorimotor co-ordination of consummatory behaviour and the development of a `response set' in motor preparatory processes for skilled responses, dopamine in the ventral striatum influences the impact of reward-related stimuli on appetitive aspects of behaviour. The circumstances under which the striatal dopamine projections are normally active to effect these functions are defined by studies which attempt to correlate firing in single units or neurochemical indices of dopamine activity with environmental conditions, internal states and behaviour. KW - dopamine KW - dorsal_striatum KW - striatum KW - ventral_striatum AU - Robbins, Trevor AU - Everitt, Barry PY - 1992/04// UR - http://dx.doi.org/10.1016/1044-5765(92)90010-Y ER -

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