pFlexAna: detecting conformational changes in remotely related proteins

by: Anshul Nigham, Lisa Tucker-Kellogg, Ivana Mihalek, Chandra Verma, David Hsu

Nucl. Acids Res. (13 May 2008), gkn259.

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摘要

The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster. pFlexAna is available at http://bigbird.comp.nus.edu.sg/pfa2/. 10.1093/nar/gkn259

@article{Nigham:2008, abstract = {The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster. pFlexAna is available at http://bigbird.comp.nus.edu.sg/pfa2/. 10.1093/nar/gkn259}, author = {Nigham, Anshul and Tucker-Kellogg, Lisa and Mihalek, Ivana and Verma, Chandra and Hsu, David }, citeulike-article-id = {2954960}, doi = {10.1093/nar/gkn259}, journal = {Nucl. Acids Res.}, keywords = {pflexana}, month = {May}, pages = {gkn259+}, posted-at = {2008-07-03 06:03:02}, priority = {2}, title = {pFlexAna: detecting conformational changes in remotely related proteins}, url = {http://dx.doi.org/10.1093/nar/gkn259}, year = {2008} }

RIS record

TY - JOUR ID - Nigham:2008 L3 - citeulike-article-id:2954960 TI - pFlexAna: detecting conformational changes in remotely related proteins JF - Nucl. Acids Res. SP - gkn259 N2 - The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster. pFlexAna is available at http://bigbird.comp.nus.edu.sg/pfa2/. 10.1093/nar/gkn259 KW - pflexana AU - Nigham, Anshul AU - Tucker-Kellogg, Lisa AU - Mihalek, Ivana AU - Verma, Chandra AU - Hsu, David PY - 2008/05/13/ UR - http://dx.doi.org/10.1093/nar/gkn259 ER -

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