Orbitofrontal cortex, decision-making and drug addiction

by: G Schoenbaum, MR Roesch, TA Stalnaker

Trends in Neurosciences, Vol. 29, No. 2. (February 2006), pp. 116-124.

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摘要

The orbitofrontal cortex, as a part of prefrontal cortex, is implicated in executive function. However, within this broad region, the orbitofrontal cortex is distinguished by its unique pattern of connections with crucial subcortical associative learning nodes, such as basolateral amygdala and nucleus accumbens. By virtue of these connections, the orbitofrontal cortex is uniquely positioned to use associative information to project into the future, and to use the value of perceived or expected outcomes to guide decisions. This review will discuss recent evidence that supports this proposal and will examine evidence that loss of this signal, as the result of drug-induced changes in these brain circuits, might account for the maladaptive decision-making that characterizes drug addiction.

@article{citeulike:482098, abstract = {The orbitofrontal cortex, as a part of prefrontal cortex, is implicated in executive function. However, within this broad region, the orbitofrontal cortex is distinguished by its unique pattern of connections with crucial subcortical associative learning nodes, such as basolateral amygdala and nucleus accumbens. By virtue of these connections, the orbitofrontal cortex is uniquely positioned to use associative information to project into the future, and to use the value of perceived or expected outcomes to guide decisions. This review will discuss recent evidence that supports this proposal and will examine evidence that loss of this signal, as the result of drug-induced changes in these brain circuits, might account for the maladaptive decision-making that characterizes drug addiction.}, author = {Schoenbaum, G. and Roesch, M. R. and Stalnaker, T. A. }, citeulike-article-id = {482098}, doi = {10.1016/j.tins.2005.12.006}, journal = {Trends in Neurosciences}, keywords = {decision, drugs, review}, month = {February}, number = {2}, pages = {116--124}, posted-at = {2008-01-04 12:46:50}, priority = {2}, title = {Orbitofrontal cortex, decision-making and drug addiction}, url = {http://dx.doi.org/10.1016/j.tins.2005.12.006}, volume = {29}, year = {2006} }

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TY - JOUR ID - citeulike:482098 L3 - citeulike-article-id:482098 TI - Orbitofrontal cortex, decision-making and drug addiction JF - Trends in Neurosciences VL - 29 IS - 2 SP - 116 EP - 124 N2 - The orbitofrontal cortex, as a part of prefrontal cortex, is implicated in executive function. However, within this broad region, the orbitofrontal cortex is distinguished by its unique pattern of connections with crucial subcortical associative learning nodes, such as basolateral amygdala and nucleus accumbens. By virtue of these connections, the orbitofrontal cortex is uniquely positioned to use associative information to project into the future, and to use the value of perceived or expected outcomes to guide decisions. This review will discuss recent evidence that supports this proposal and will examine evidence that loss of this signal, as the result of drug-induced changes in these brain circuits, might account for the maladaptive decision-making that characterizes drug addiction. KW - decision KW - drugs KW - review AU - Schoenbaum, G AU - Roesch, MR AU - Stalnaker, TA PY - 2006/02// UR - http://dx.doi.org/10.1016/j.tins.2005.12.006 ER -

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