Computer prediction of drug resistance mutations in proteins

by: Zhi W Cao, Lian Y Han, Chan J Zheng, Zhi L Ji, Xin Chen, Hong H Lin, Yu Z Chen

Drug Discovery Today, Vol. 10, No. 7. (1 April 2005), pp. 521-529.

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摘要

Drug resistance is of increasing concern in the treatment of infectious diseases and cancer. Mutation in drug-interacting disease proteins is one of the primary causes for resistance particularly against anti-infectious drugs. Prediction of resistance mutations in these proteins is valuable both for the molecular dissection of drug resistance mechanisms and for predicting features that guide the design of new agents to counter resistant strains. Several protein structure- and sequence-based computer methods have been explored for mechanistic study and prediction of resistance mutations. These methods and their usefulness are reviewed here.

@article{citeulike:454571, abstract = {Drug resistance is of increasing concern in the treatment of infectious diseases and cancer. Mutation in drug-interacting disease proteins is one of the primary causes for resistance particularly against anti-infectious drugs. Prediction of resistance mutations in these proteins is valuable both for the molecular dissection of drug resistance mechanisms and for predicting features that guide the design of new agents to counter resistant strains. Several protein structure- and sequence-based computer methods have been explored for mechanistic study and prediction of resistance mutations. These methods and their usefulness are reviewed here.}, author = {Cao, Zhi W. and Han, Lian Y. and Zheng, Chan J. and Ji, Zhi L. and Chen, Xin and Lin, Hong H. and Chen, Yu Z. }, citeulike-article-id = {454571}, doi = {10.1016/S1359-6446(05)03377-5}, journal = {Drug Discovery Today}, keywords = {drug-resistance, proteomics}, month = {April}, number = {7}, pages = {521--529}, posted-at = {2007-08-22 15:57:31}, priority = {2}, title = {Computer prediction of drug resistance mutations in proteins}, url = {http://dx.doi.org/10.1016/S1359-6446(05)03377-5}, volume = {10}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:454571 L3 - citeulike-article-id:454571 TI - Computer prediction of drug resistance mutations in proteins JF - Drug Discovery Today VL - 10 IS - 7 SP - 521 EP - 529 N2 - Drug resistance is of increasing concern in the treatment of infectious diseases and cancer. Mutation in drug-interacting disease proteins is one of the primary causes for resistance particularly against anti-infectious drugs. Prediction of resistance mutations in these proteins is valuable both for the molecular dissection of drug resistance mechanisms and for predicting features that guide the design of new agents to counter resistant strains. Several protein structure- and sequence-based computer methods have been explored for mechanistic study and prediction of resistance mutations. These methods and their usefulness are reviewed here. KW - drug-resistance KW - proteomics AU - Cao, Zhi AU - Han, Lian AU - Zheng, Chan AU - Ji, Zhi AU - Chen, Xin AU - Lin, Hong AU - Chen, Yu PY - 2005/04/01/ UR - http://dx.doi.org/10.1016/S1359-6446(05)03377-5 ER -

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