The Consensus Coding Sequences of Human Breast and Colorectal Cancers

@article{citeulike:835275, abstract = {The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we have determined the sequence of well-annotated human protein coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of \~{}90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology. 10.1126/science.1133427}, author = {Sjoblom, Tobias and Jones, Sian and Wood, Laura D. and Parsons, Williams D. and Lin, Jimmy and Barber, Thomas and Mandelker, Diana and Leary, Rebecca J. and Ptak, Janine and Silliman, Natalie and Szabo, Steve and Buckhaults, Phillip and Farrell, Christopher and Meeh, Paul and Markowitz, Sanford D. and Willis, Joseph and Dawson, Dawn and Willson, James K. and Gazdar, Adi F. and Hartigan, James and Wu, Leo and Liu, Changsheng and Parmigiani, Giovanni and Park, Ben H. and Bachman, Kurtis E. and Papadopoulos, Nickolas and Vogelstein, Bert and Kinzler, Kenneth W. and Velculescu, Victor E. }, citeulike-article-id = {835275}, doi = {10.1126/science.1133427}, journal = {Science}, month = {September}, pages = {1133427+}, posted-at = {2008-05-03 08:41:56}, priority = {2}, title = {The Consensus Coding Sequences of Human Breast and Colorectal Cancers}, url = {http://dx.doi.org/10.1126/science.1133427}, year = {2006} }

TY - JOUR ID - citeulike:835275 L3 - citeulike-article-id:835275 TI - The Consensus Coding Sequences of Human Breast and Colorectal Cancers JF - Science SP - 1133427 N2 - The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we have determined the sequence of well-annotated human protein coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ~90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology. 10.1126/science.1133427 AU - Sjoblom, Tobias AU - Jones, Sian AU - Wood, Laura AU - Parsons, Williams AU - Lin, Jimmy AU - Barber, Thomas AU - Mandelker, Diana AU - Leary, Rebecca AU - Ptak, Janine AU - Silliman, Natalie AU - Szabo, Steve AU - Buckhaults, Phillip AU - Farrell, Christopher AU - Meeh, Paul AU - Markowitz, Sanford AU - Willis, Joseph AU - Dawson, Dawn AU - Willson, James AU - Gazdar, Adi AU - Hartigan, James AU - Wu, Leo AU - Liu, Changsheng AU - Parmigiani, Giovanni AU - Park, Ben AU - Bachman, Kurtis AU - Papadopoulos, Nickolas AU - Vogelstein, Bert AU - Kinzler, Kenneth AU - Velculescu, Victor PY - 2006/09/07/ UR - http://dx.doi.org/10.1126/science.1133427 ER -