Phenotypic variation in bacteria: the role of feedback regulation

by: Wiep K Smits, Oscar P Kuipers, Jan-Willem Veening

Nature Reviews Microbiology, Vol. 4, No. 4., pp. 259-271.

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摘要

To survive in rapidly changing environmental conditions, bacteria have evolved a diverse set of regulatory pathways that govern various adaptive responses. Recent research has reinforced the notion that bacteria use feedback-based circuitry to generate population heterogeneity in natural situations. Using artificial gene networks, it has been shown that a relatively simple 'wiring' of a bacterial genetic system can generate two or more stable subpopulations within an overall genetically homogeneous population. This review discusses the ubiquity of these processes throughout nature, as well as the presumed molecular mechanisms responsible for the heterogeneity observed in a selection of bacterial species.

@article{citeulike:554114, abstract = {To survive in rapidly changing environmental conditions, bacteria have evolved a diverse set of regulatory pathways that govern various adaptive responses. Recent research has reinforced the notion that bacteria use feedback-based circuitry to generate population heterogeneity in natural situations. Using artificial gene networks, it has been shown that a relatively simple 'wiring' of a bacterial genetic system can generate two or more stable subpopulations within an overall genetically homogeneous population. This review discusses the ubiquity of these processes throughout nature, as well as the presumed molecular mechanisms responsible for the heterogeneity observed in a selection of bacterial species.}, author = {Smits, Wiep K. and Kuipers, Oscar P. and Veening, Jan-Willem }, citeulike-article-id = {554114}, doi = {http://dx.doi.org/10.1038/nrmicro1381}, issn = {1740-1526}, journal = {Nature Reviews Microbiology}, keywords = {bacteria, bistability, noise}, number = {4}, pages = {259--271}, posted-at = {2008-03-25 17:25:01}, priority = {2}, publisher = {Nature Publishing Group}, title = {Phenotypic variation in bacteria: the role of feedback regulation}, url = {http://dx.doi.org/10.1038/nrmicro1381}, volume = {4} }

RIS record

TY - JOUR ID - citeulike:554114 L3 - citeulike-article-id:554114 N2 - To survive in rapidly changing environmental conditions, bacteria have evolved a diverse set of regulatory pathways that govern various adaptive responses. Recent research has reinforced the notion that bacteria use feedback-based circuitry to generate population heterogeneity in natural situations. Using artificial gene networks, it has been shown that a relatively simple 'wiring' of a bacterial genetic system can generate two or more stable subpopulations within an overall genetically homogeneous population. This review discusses the ubiquity of these processes throughout nature, as well as the presumed molecular mechanisms responsible for the heterogeneity observed in a selection of bacterial species. IS - 4 JF - Nature Reviews Microbiology SN - 1740-1526 EP - 271 TI - Phenotypic variation in bacteria: the role of feedback regulation PB - Nature Publishing Group VL - 4 SP - 259 KW - bacteria KW - bistability KW - noise AU - Smits, Wiep AU - Kuipers, Oscar AU - Veening, Jan-Willem UR - http://dx.doi.org/10.1038/nrmicro1381 ER -

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