Stochasticity and Cell Fate

by: Richard Losick, Claude Desplan

Science, Vol. 320, No. 5872. (4 April 2008), pp. 65-68.

View FullText article

DOI, HighWire, Pubmed, Hubmed

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

lukaswindhager, balabu, margaritis, paulschlesinger, davidlott, GEB (group), josedavid

Find related articles with these CiteULike tags

bistability, bistable, cell, cell_fate, cells, death, fly, noise, review, spatial, stochastic, stochasticity, switches, theo-bio

摘要

Fundamental to living cells is the capacity to differentiate into subtypes with specialized attributes. Understanding the way cells acquire their fates is a major challenge in developmental biology. How cells adopt a particular fate is usually thought of as being deterministic, and in the large majority of cases it is. That is, cells acquire their fate by virtue of their lineage or their proximity to an inductive signal from another cell. In some cases, however, and in organisms ranging from bacteria to humans, cells choose one or another pathway of differentiation stochastically, without apparent regard to environment or history. Stochasticity has important mechanistic requirements. We speculate on why stochasticity is advantageousand even critical in some circumstancesto the individual, the colony, or the species. 10.1126/science.1147888

@article{citeulike:2628123, abstract = {Fundamental to living cells is the capacity to differentiate into subtypes with specialized attributes. Understanding the way cells acquire their fates is a major challenge in developmental biology. How cells adopt a particular fate is usually thought of as being deterministic, and in the large majority of cases it is. That is, cells acquire their fate by virtue of their lineage or their proximity to an inductive signal from another cell. In some cases, however, and in organisms ranging from bacteria to humans, cells choose one or another pathway of differentiation stochastically, without apparent regard to environment or history. Stochasticity has important mechanistic requirements. We speculate on why stochasticity is advantageousand even critical in some circumstancesto the individual, the colony, or the species. 10.1126/science.1147888}, author = {Losick, Richard and Desplan, Claude }, citeulike-article-id = {2628123}, doi = {http://dx.doi.org/10.1126/science.1147888}, journal = {Science}, keywords = {bistability, cell\_fate, review, stochasticity}, month = {April}, number = {5872}, pages = {65--68}, posted-at = {2008-04-07 10:48:31}, priority = {2}, title = {Stochasticity and Cell Fate}, url = {http://dx.doi.org/10.1126/science.1147888}, volume = {320}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2628123 L3 - citeulike-article-id:2628123 N2 - Fundamental to living cells is the capacity to differentiate into subtypes with specialized attributes. Understanding the way cells acquire their fates is a major challenge in developmental biology. How cells adopt a particular fate is usually thought of as being deterministic, and in the large majority of cases it is. That is, cells acquire their fate by virtue of their lineage or their proximity to an inductive signal from another cell. In some cases, however, and in organisms ranging from bacteria to humans, cells choose one or another pathway of differentiation stochastically, without apparent regard to environment or history. Stochasticity has important mechanistic requirements. We speculate on why stochasticity is advantageousand even critical in some circumstancesto the individual, the colony, or the species. 10.1126/science.1147888 IS - 5872 JF - Science EP - 68 TI - Stochasticity and Cell Fate VL - 320 SP - 65 KW - bistability KW - cell_fate KW - review KW - stochasticity AU - Losick, Richard AU - Desplan, Claude PY - 2008/04/04/ UR - http://dx.doi.org/10.1126/science.1147888 ER -

RIS BibTeX