Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II

@article{citeulike:2606114, abstract = {Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation. 10.1126/science.1150843}, author = {Core, Leighton J. and Lis, John T. }, citeulike-article-id = {2606114}, doi = {http://dx.doi.org/10.1126/science.1150843}, journal = {Science}, keywords = {pause, pauses, regulation, transcription}, month = {March}, number = {5871}, pages = {1791--1792}, posted-at = {2008-03-28 12:37:15}, priority = {2}, title = {Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II}, url = {http://dx.doi.org/10.1126/science.1150843}, volume = {319}, year = {2008} }

TY - JOUR ID - citeulike:2606114 L3 - citeulike-article-id:2606114 N2 - Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation. 10.1126/science.1150843 IS - 5871 JF - Science EP - 1792 TI - Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II VL - 319 SP - 1791 KW - pause KW - pauses KW - regulation KW - transcription AU - Core, Leighton AU - Lis, John PY - 2008/03/28/ UR - http://dx.doi.org/10.1126/science.1150843 ER -