The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae

by: Jerome T Mettetal, Dale Muzzey, Carlos Gomez-Uribe, Alexander van Oudenaarden

Science, Vol. 319, No. 5862. (25 January 2008), pp. 482-484.

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摘要

The propagation of information through signaling cascades spans a wide range of time scales, including the rapid ligand-receptor interaction and the much slower response of downstream gene expression. To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae. We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli. 10.1126/science.1151582

@article{citeulike:2288327, abstract = {The propagation of information through signaling cascades spans a wide range of time scales, including the rapid ligand-receptor interaction and the much slower response of downstream gene expression. To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae. We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli. 10.1126/science.1151582}, author = {Mettetal, Jerome T. and Muzzey, Dale and Gomez-Uribe, Carlos and van Oudenaarden, Alexander }, citeulike-article-id = {2288327}, doi = {http://dx.doi.org/10.1126/science.1151582}, journal = {Science}, keywords = {gene-circuits, gene-expression, gene-networks, gene-regulation, negative\_feedback}, month = {January}, number = {5862}, pages = {482--484}, posted-at = {2008-01-30 10:54:02}, priority = {5}, title = {The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae}, url = {http://dx.doi.org/10.1126/science.1151582}, volume = {319}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2288327 L3 - citeulike-article-id:2288327 N2 - The propagation of information through signaling cascades spans a wide range of time scales, including the rapid ligand-receptor interaction and the much slower response of downstream gene expression. To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae. We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli. 10.1126/science.1151582 IS - 5862 JF - Science EP - 484 TI - The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae VL - 319 SP - 482 KW - gene-circuits KW - gene-expression KW - gene-networks KW - gene-regulation KW - negative_feedback AU - Mettetal, Jerome AU - Muzzey, Dale AU - Gomez-Uribe, Carlos AU - van Oudenaarden, Alexander PY - 2008/01/25/ UR - http://dx.doi.org/10.1126/science.1151582 ER -

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