Dynamical quorum sensing: Population density encoded in cellular dynamics

by: Silvia De Monte, Francesco D'ovidio, Sune Dano, Preben G Sorensen

Proceedings of the National Academy of Sciences, Vol. 104, No. 47. (20 November 2007), pp. 18377-18381.

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摘要

Mutual synchronization by exchange of chemicals is a mechanism for the emergence of collective dynamics in cellular populations. General theories exist on the transition to coherence, but no quantitative, experimental demonstration has been given. Here, we present a modeling and experimental analysis of cell-density-dependent glycolytic oscillations in yeast. We study the disappearance of oscillations at low cell density and show that this phenomenon occurs synchronously in all cells and not by desynchronization, as previously expected. This study identifies a general scenario for the emergence of collective cellular oscillations and suggests a quorum-sensing mechanism by which the cell density information is encoded in the intracellular dynamical state. 10.1073/pnas.0706089104

@article{citeulike:1949987, abstract = {Mutual synchronization by exchange of chemicals is a mechanism for the emergence of collective dynamics in cellular populations. General theories exist on the transition to coherence, but no quantitative, experimental demonstration has been given. Here, we present a modeling and experimental analysis of cell-density-dependent glycolytic oscillations in yeast. We study the disappearance of oscillations at low cell density and show that this phenomenon occurs synchronously in all cells and not by desynchronization, as previously expected. This study identifies a general scenario for the emergence of collective cellular oscillations and suggests a quorum-sensing mechanism by which the cell density information is encoded in the intracellular dynamical state. 10.1073/pnas.0706089104}, author = {De Monte, Silvia and D'ovidio, Francesco and Dano, Sune and Sorensen, Preben G. }, citeulike-article-id = {1949987}, doi = {http://dx.doi.org/10.1073/pnas.0706089104}, journal = {Proceedings of the National Academy of Sciences}, keywords = {fluctuations, population\_density, quorum\_sensing}, month = {November}, number = {47}, pages = {18377--18381}, posted-at = {2007-11-21 11:04:41}, priority = {5}, title = {Dynamical quorum sensing: Population density encoded in cellular dynamics}, url = {http://dx.doi.org/10.1073/pnas.0706089104}, volume = {104}, year = {2007} }

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TY - JOUR ID - citeulike:1949987 L3 - citeulike-article-id:1949987 N2 - Mutual synchronization by exchange of chemicals is a mechanism for the emergence of collective dynamics in cellular populations. General theories exist on the transition to coherence, but no quantitative, experimental demonstration has been given. Here, we present a modeling and experimental analysis of cell-density-dependent glycolytic oscillations in yeast. We study the disappearance of oscillations at low cell density and show that this phenomenon occurs synchronously in all cells and not by desynchronization, as previously expected. This study identifies a general scenario for the emergence of collective cellular oscillations and suggests a quorum-sensing mechanism by which the cell density information is encoded in the intracellular dynamical state. 10.1073/pnas.0706089104 IS - 47 JF - Proceedings of the National Academy of Sciences EP - 18381 TI - Dynamical quorum sensing: Population density encoded in cellular dynamics VL - 104 SP - 18377 KW - fluctuations KW - population_density KW - quorum_sensing AU - De Monte, Silvia AU - D'ovidio, Francesco AU - Dano, Sune AU - Sorensen, Preben PY - 2007/11/20/ UR - http://dx.doi.org/10.1073/pnas.0706089104 ER -

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