Molecular level stochastic model for competence cycles in Bacillus subtilis

by: Daniel Schultz, Ben, Jose N Onuchic, Peter G Wolynes

Proceedings of the National Academy of Sciences, Vol. 104, No. 45. (6 November 2007), pp. 17582-17587.

View FullText article

DOI, HighWire, Pubmed, Hubmed

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

jjray, balabu, lshaw, margaritis

Find related articles with these CiteULike tags

bacillus_subtilis, bsubtilis, competence, fluctuations, mathematical_model, modeling, noise, noise_bio, stochastic, stochasticity, timing

摘要

The role of stochasticity and noise in controlling genetic circuits is investigated in the context of transitions into and from competence in Bacillus subtilis. Recent experiments have demonstrated that bistability is not necessary for this function, but that the existence of one stable fixed point (vegetation) and an excitable unstable one (competence) is sufficient. Stochasticity therefore plays a crucial role in this excitation. Noise can be generated by discrete events such as RNA and protein synthesis and their degradation. We consider an alternative noise source connected with the protein binding/unbinding to the DNA. A theoretical model that includes this "nonadiabatic" mechanism appears to produce a better agreement with experiments than models where only the adiabatic limit is considered, suggesting that this nonconventional stochasticity source may be important for biological functions. 10.1073/pnas.0707965104

@article{citeulike:1875319, abstract = {The role of stochasticity and noise in controlling genetic circuits is investigated in the context of transitions into and from competence in Bacillus subtilis. Recent experiments have demonstrated that bistability is not necessary for this function, but that the existence of one stable fixed point (vegetation) and an excitable unstable one (competence) is sufficient. Stochasticity therefore plays a crucial role in this excitation. Noise can be generated by discrete events such as RNA and protein synthesis and their degradation. We consider an alternative noise source connected with the protein binding/unbinding to the DNA. A theoretical model that includes this "nonadiabatic" mechanism appears to produce a better agreement with experiments than models where only the adiabatic limit is considered, suggesting that this nonconventional stochasticity source may be important for biological functions. 10.1073/pnas.0707965104}, author = {Schultz, Daniel and Ben and Onuchic, Jose N. and Wolynes, Peter G. }, citeulike-article-id = {1875319}, doi = {10.1073/pnas.0707965104}, journal = {Proceedings of the National Academy of Sciences}, keywords = {bsubtilis, competence, fluctuations, noise, stochasticity}, month = {November}, number = {45}, pages = {17582--17587}, posted-at = {2007-11-07 17:44:50}, priority = {3}, title = {Molecular level stochastic model for competence cycles in Bacillus subtilis}, url = {http://dx.doi.org/10.1073/pnas.0707965104}, volume = {104}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1875319 L3 - citeulike-article-id:1875319 TI - Molecular level stochastic model for competence cycles in Bacillus subtilis JF - Proceedings of the National Academy of Sciences VL - 104 IS - 45 SP - 17582 EP - 17587 N2 - The role of stochasticity and noise in controlling genetic circuits is investigated in the context of transitions into and from competence in Bacillus subtilis. Recent experiments have demonstrated that bistability is not necessary for this function, but that the existence of one stable fixed point (vegetation) and an excitable unstable one (competence) is sufficient. Stochasticity therefore plays a crucial role in this excitation. Noise can be generated by discrete events such as RNA and protein synthesis and their degradation. We consider an alternative noise source connected with the protein binding/unbinding to the DNA. A theoretical model that includes this "nonadiabatic" mechanism appears to produce a better agreement with experiments than models where only the adiabatic limit is considered, suggesting that this nonconventional stochasticity source may be important for biological functions. 10.1073/pnas.0707965104 KW - bsubtilis KW - competence KW - fluctuations KW - noise KW - stochasticity AU - Schultz, Daniel AU - Ben AU - Onuchic, Jose AU - Wolynes, Peter PY - 2007/11/06/ UR - http://dx.doi.org/10.1073/pnas.0707965104 ER -

RIS BibTeX