Living with noisy genes: how cells function reliably with inherent variability in gene expression.

by: N Maheshri, EK O'Shea

Annu Rev Biophys Biomol Struct, Vol. 36 (2007), pp. 413-434.

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摘要

Within a population of genetically identical cells there can be significant variation, or noise, in gene expression. Yet even with this inherent variability, cells function reliably. This review focuses on our understanding of noise at the level of both single genes and genetic regulatory networks, emphasizing comparisons between theoretical models and experimental results whenever possible. To highlight the importance of noise, we particularly emphasize examples in which a stochastic description of gene expression leads to a qualitatively different outcome than a deterministic one.

@article{citeulike:1783204, abstract = {Within a population of genetically identical cells there can be significant variation, or noise, in gene expression. Yet even with this inherent variability, cells function reliably. This review focuses on our understanding of noise at the level of both single genes and genetic regulatory networks, emphasizing comparisons between theoretical models and experimental results whenever possible. To highlight the importance of noise, we particularly emphasize examples in which a stochastic description of gene expression leads to a qualitatively different outcome than a deterministic one.}, address = {Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. narendra@mit.edu}, author = {Maheshri, N. and O'Shea, E. K. }, citeulike-article-id = {1783204}, doi = {http://dx.doi.org/10.1146/annurev.biophys.36.040306.132705}, issn = {1056-8700}, journal = {Annu Rev Biophys Biomol Struct}, keywords = {fluctuations, noise, review, stochasticity}, pages = {413--434}, posted-at = {2007-11-01 14:16:52}, priority = {2}, title = {Living with noisy genes: how cells function reliably with inherent variability in gene expression.}, url = {http://dx.doi.org/10.1146/annurev.biophys.36.040306.132705}, volume = {36}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1783204 L3 - citeulike-article-id:1783204 N2 - Within a population of genetically identical cells there can be significant variation, or noise, in gene expression. Yet even with this inherent variability, cells function reliably. This review focuses on our understanding of noise at the level of both single genes and genetic regulatory networks, emphasizing comparisons between theoretical models and experimental results whenever possible. To highlight the importance of noise, we particularly emphasize examples in which a stochastic description of gene expression leads to a qualitatively different outcome than a deterministic one. JF - Annu Rev Biophys Biomol Struct SN - 1056-8700 AD - Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. narendra@mit.edu EP - 434 TI - Living with noisy genes: how cells function reliably with inherent variability in gene expression. VL - 36 SP - 413 KW - fluctuations KW - noise KW - review KW - stochasticity AU - Maheshri, N AU - O'Shea, EK PY - 2007/// UR - http://dx.doi.org/10.1146/annurev.biophys.36.040306.132705 ER -

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