A metabolic sensor governing cell size in bacteria.

@article{citeulike:1524569, abstract = {Nutrient availability is one of the strongest determinants of cell size. When grown in rich media, single-celled organisms such as yeast and bacteria can be up to twice the size of their slow-growing counterparts. The ability to modulate size in a nutrient-dependent manner requires cells to: (1) detect when they have reached the appropriate mass for a given growth rate and (2) transmit this information to the division apparatus. We report the identification of a metabolic sensor that couples nutritional availability to division in Bacillus subtilis. A key component of this sensor is an effector, UgtP, which localizes to the division site in a nutrient-dependent manner and inhibits assembly of the tubulin-like cell division protein FtsZ. This sensor serves to maintain a constant ratio of FtsZ rings to cell length regardless of growth rate and ensures that cells reach the appropriate mass and complete chromosome segregation prior to cytokinesis.}, address = {Department of Biology, Washington University, St. Louis, MO 63130, USA.}, author = {Weart, R. B. and Lee, A. H. and Chien, A. C. and Haeusser, D. P. and Hill, N. S. and Levin, P. A. }, citeulike-article-id = {1524569}, doi = {http://dx.doi.org/10.1016/j.cell.2007.05.043}, issn = {0092-8674}, journal = {Cell}, keywords = {bsubtilis, growth\_rate}, month = {July}, number = {2}, pages = {335--347}, posted-at = {2007-08-01 12:03:48}, priority = {2}, title = {A metabolic sensor governing cell size in bacteria.}, url = {http://dx.doi.org/10.1016/j.cell.2007.05.043}, volume = {130}, year = {2007} }

TY - JOUR ID - citeulike:1524569 L3 - citeulike-article-id:1524569 N2 - Nutrient availability is one of the strongest determinants of cell size. When grown in rich media, single-celled organisms such as yeast and bacteria can be up to twice the size of their slow-growing counterparts. The ability to modulate size in a nutrient-dependent manner requires cells to: (1) detect when they have reached the appropriate mass for a given growth rate and (2) transmit this information to the division apparatus. We report the identification of a metabolic sensor that couples nutritional availability to division in Bacillus subtilis. A key component of this sensor is an effector, UgtP, which localizes to the division site in a nutrient-dependent manner and inhibits assembly of the tubulin-like cell division protein FtsZ. This sensor serves to maintain a constant ratio of FtsZ rings to cell length regardless of growth rate and ensures that cells reach the appropriate mass and complete chromosome segregation prior to cytokinesis. IS - 2 JF - Cell SN - 0092-8674 AD - Department of Biology, Washington University, St. Louis, MO 63130, USA. EP - 347 TI - A metabolic sensor governing cell size in bacteria. VL - 130 SP - 335 KW - bsubtilis KW - growth_rate AU - Weart, RB AU - Lee, AH AU - Chien, AC AU - Haeusser, DP AU - Hill, NS AU - Levin, PA PY - 2007/07/27/ UR - http://dx.doi.org/10.1016/j.cell.2007.05.043 ER -