A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.

@article{citeulike:1699667, abstract = {Double muscling is a trait previously described in several mammalian species including cattle and sheep and is caused by mutations in the myostatin (MSTN) gene (previously referred to as GDF8). Here we describe a new mutation in MSTN found in the whippet dog breed that results in a double-muscled phenotype known as the "bully" whippet. Individuals with this phenotype carry two copies of a two-base-pair deletion in the third exon of MSTN leading to a premature stop codon at amino acid 313. Individuals carrying only one copy of the mutation are, on average, more muscular than wild-type individuals (p = 7.43 x 10(-6); Kruskal-Wallis Test) and are significantly faster than individuals carrying the wild-type genotype in competitive racing events (Kendall's nonparametric measure, tau = 0.3619; p approximately 0.00028). These results highlight the utility of performance-enhancing polymorphisms, marking the first time a mutation in MSTN has been quantitatively linked to increased athletic performance.}, address = {National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.}, author = {Mosher, D. S. and Quignon, P. and Bustamante, C. D. and Sutter, N. B. and Mellersh, C. S. and Parker, H. G. and Ostrander, E. A. }, citeulike-article-id = {1699667}, doi = {http://dx.doi.org/10.1371/journal.pgen.0030079}, issn = {1553-7404}, journal = {PLoS Genet}, keywords = {dog, genetics}, month = {May}, number = {5}, posted-at = {2007-09-27 10:01:54}, priority = {2}, title = {A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.}, url = {http://dx.doi.org/10.1371/journal.pgen.0030079}, volume = {3}, year = {2007} }

TY - JOUR ID - citeulike:1699667 L3 - citeulike-article-id:1699667 TI - A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. JF - PLoS Genet VL - 3 IS - 5 AD - National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America. SN - 1553-7404 N2 - Double muscling is a trait previously described in several mammalian species including cattle and sheep and is caused by mutations in the myostatin (MSTN) gene (previously referred to as GDF8). Here we describe a new mutation in MSTN found in the whippet dog breed that results in a double-muscled phenotype known as the "bully" whippet. Individuals with this phenotype carry two copies of a two-base-pair deletion in the third exon of MSTN leading to a premature stop codon at amino acid 313. Individuals carrying only one copy of the mutation are, on average, more muscular than wild-type individuals (p = 7.43 x 10(-6); Kruskal-Wallis Test) and are significantly faster than individuals carrying the wild-type genotype in competitive racing events (Kendall's nonparametric measure, tau = 0.3619; p approximately 0.00028). These results highlight the utility of performance-enhancing polymorphisms, marking the first time a mutation in MSTN has been quantitatively linked to increased athletic performance. KW - dog KW - genetics AU - Mosher, DS AU - Quignon, P AU - Bustamante, CD AU - Sutter, NB AU - Mellersh, CS AU - Parker, HG AU - Ostrander, EA PY - 2007/05/25/ UR - http://dx.doi.org/10.1371/journal.pgen.0030079 ER -