The return of Phineas Gage: clues about the brain from the skull of a famous patient.

by: H Damasio, T Grabowski, R Frank, AM Galaburda, AR Damasio

Science, Vol. 264, No. 5162. (20 May 1994), pp. 1102-1105.

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摘要

When the landmark patient Phineas Gage died in 1861, no autopsy was performed, but his skull was later recovered. The brain lesion that caused the profound personality changes for which his case became famous has been presumed to have involved the left frontal region, but questions have been raised about the involvement of other regions and about the exact placement of the lesion within the vast frontal territory. Measurements from Gage's skull and modern neuroimaging techniques were used to reconstitute the accident and determine the probable location of the lesion. The damage involved both left and right prefrontal cortices in a pattern that, as confirmed by Gage's modern counterparts, causes a defect in rational decision making and the processing of emotion.

@article{citeulike:2613941, abstract = {When the landmark patient Phineas Gage died in 1861, no autopsy was performed, but his skull was later recovered. The brain lesion that caused the profound personality changes for which his case became famous has been presumed to have involved the left frontal region, but questions have been raised about the involvement of other regions and about the exact placement of the lesion within the vast frontal territory. Measurements from Gage's skull and modern neuroimaging techniques were used to reconstitute the accident and determine the probable location of the lesion. The damage involved both left and right prefrontal cortices in a pattern that, as confirmed by Gage's modern counterparts, causes a defect in rational decision making and the processing of emotion.}, address = {Department of Neurology, University of Iowa Hospitals \& Clinics, Iowa City 52242.}, author = {Damasio, H. and Grabowski, T. and Frank, R. and Galaburda, A. M. and Damasio, A. R. }, citeulike-article-id = {2613941}, issn = {0036-8075}, journal = {Science}, keywords = {lesion, prefrontal}, month = {May}, number = {5162}, pages = {1102--1105}, posted-at = {2008-05-12 15:45:09}, priority = {2}, title = {The return of Phineas Gage: clues about the brain from the skull of a famous patient.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8178168}, volume = {264}, year = {1994} }

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TY - JOUR ID - citeulike:2613941 L3 - citeulike-article-id:2613941 TI - The return of Phineas Gage: clues about the brain from the skull of a famous patient. JF - Science VL - 264 IS - 5162 SP - 1102 EP - 1105 AD - Department of Neurology, University of Iowa Hospitals & Clinics, Iowa City 52242. SN - 0036-8075 N2 - When the landmark patient Phineas Gage died in 1861, no autopsy was performed, but his skull was later recovered. The brain lesion that caused the profound personality changes for which his case became famous has been presumed to have involved the left frontal region, but questions have been raised about the involvement of other regions and about the exact placement of the lesion within the vast frontal territory. Measurements from Gage's skull and modern neuroimaging techniques were used to reconstitute the accident and determine the probable location of the lesion. The damage involved both left and right prefrontal cortices in a pattern that, as confirmed by Gage's modern counterparts, causes a defect in rational decision making and the processing of emotion. KW - lesion KW - prefrontal AU - Damasio, H AU - Grabowski, T AU - Frank, R AU - Galaburda, AM AU - Damasio, AR PY - 1994/05/20/ UR - http://view.ncbi.nlm.nih.gov/pubmed/8178168 ER -

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