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kengg's small-molecule [51 articles]

当前文献位于 kengg's 文献库 标签分类为 small-molecule. You can also see everyone's small-molecule.
  • Bleomycin-induced DNA lesions at mutational hot spots: implications for the mechanism of double-strand cleavage
    Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 21. (November 1990), pp. 8350-8354.
    by RJ Steighner, LF Povirk
    posted to small-molecule repair by kengg on 2008-08-27 18:32:11 as **
  • Epigenetic remodeling of the fungal secondary metabolome.
    Organic & biomolecular chemistry, Vol. 6, No. 11. (7 June 2008), pp. 1895-1897.
    by RB Williams, JC Henrikson, AR Hoover, AE Lee, RH Cichewicz
    posted to small-molecule metabolite inhibitor epigenetics by kengg on 2008-08-23 17:05:42 as ** along with 1 person and 1 group stajich Berkeley Mycology
  • Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification.
    Cancer research, Vol. 68, No. 8. (15 April 2008), pp. 2736-2744.
    by S Majid, N Kikuno, J Nelles, E Noonan, Y Tanaka, K Kawamoto, H Hirata, LC Li, H Zhao, ST Okino, RF Place, D Pookot, R Dahiya
    posted to small-molecule methylation metabolite histone flavonoid epigenetics chromatin by kengg on 2008-08-15 01:27:23 as ** along with 1 person mtagaya
  • A small molecule enhances RNA interference and promotes microRNA processing
    Nature Biotechnology, Vol. 26, No. 8. (20 July 2008), pp. 933-940.
    by Ge Shan, Yujing Li, Junliang Zhang, Wendi Li, Keith E Szulwach, Ranhui Duan, Mohammad A Faghihi, Ahmad M Khalil, Lianghua Lu, Zain Paroo, Anthony WS Chan, Zhangjie Shi, Qinghua Liu, Claes Wahlestedt, Chuan He, Peng Jin
    posted to small-rna small-molecule chemical-biology by kengg on 2008-08-13 14:12:10 as ** along with 1 person jyuh
  • Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells.
    Biochemical pharmacology, Vol. 72, No. 6. (14 September 2006), pp. 681-692.
    by MA Vargo, OH Voss, F Poustka, AJ Cardounel, E Grotewold, AI Doseff
    posted to small-molecule flavonoid apoptosis by kengg on 2008-08-08 13:31:23 as **
  • Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells.
    Biochemical pharmacology, Vol. 65, No. 10. (15 May 2003), pp. 1603-1610.
    by T Walle, TS Vincent, UK Walle
    posted to small-molecule flavonoid by kengg on 2008-08-07 15:49:27 as **
  • Systems biology in drug discovery
    Nat Biotech, Vol. 22, No. 10. (October 2004), pp. 1253-1259.
    by Eugene C Butcher, Ellen L Berg, Eric J Kunkel
    posted to systems small-molecule review by kengg on 2008-07-07 18:51:54 as ** along with 5 people and 3 groups rhem1224 tny karthikram mingzhi maburkitt TCR_Signaling Neoscientists SysbioMPI-TCells
  • Elucidating the Germination Transcriptional Program Using Small Molecules
    Plant Physiol., Vol. 147, No. 1. (1 May 2008), pp. 143-155.
    by George W Bassel, Pauline Fung, Tsz-Fung F Chow, Justin A Foong, Nicholas J Provart, Sean R Cutler
    posted to small-molecule hint by kengg on 2008-04-29 02:34:42 as **
  • The cloning of human genes using cDNA phage display and small-molecule chemical probes.
    Comb Chem High Throughput Screen, Vol. 4, No. 7. (November 2001), pp. 593-597.
    by SN Savinov, DJ Austin
    posted to phage small-molecule by kengg on 2008-03-12 17:17:49 as **
  • Identification of small molecule binding sites within proteins using phage display technology.
    Comb Chem High Throughput Screen, Vol. 4, No. 7. (November 2001), pp. 553-572.
    by DJ Rodi, GE Agoston, R Manon, R Lapcevich, SJ Green, L Makowski
    posted to phage small-molecule by kengg on 2008-03-12 17:17:13 as **
  • Integrating high-content screening and ligand-target prediction to identify mechanism of action.
    Nat Chem Biol, Vol. 4, No. 1. (January 2008), pp. 59-68.
    by DW Young, A Bender, J Hoyt, E McWhinnie, GW Chirn, CY Tao, JA Tallarico, M Labow, JL Jenkins, TJ Mitchison, Y Feng
    posted to high-throughput network small-molecule by kengg on 2008-02-13 16:09:29 as ***** along with 3 people Yanno jyuh kuhn
  • High-content single-cell drug screening with phosphospecific flow cytometry.
    Nat Chem Biol, Vol. 4, No. 2. (February 2008), pp. 132-142.
    by PO Krutzik, JM Crane, MR Clutter, GP Nolan
    posted to small-molecule by kengg on 2008-02-13 14:18:18 as ** along with 2 people jyuh Yanno
  • Non-SELEX selection of aptamers.
    J Am Chem Soc, Vol. 128, No. 5. (8 February 2006), pp. 1410-1411.
    by M Berezovski, M Musheev, A Drabovich, SN Krylov
    posted to capillary high-throughput small-molecule by kengg on 2007-09-27 16:34:21 as **
  • Capillary electrophoresis-SELEX selection of aptamers with affinity for HIV-1 reverse transcriptase.
    Anal Chem, Vol. 77, No. 19. (1 October 2005), pp. 6107-6112.
    by RK Mosing, SD Mendonsa, MT Bowser
    posted to high-throughput small-molecule by kengg on 2007-09-27 16:25:51 as **
  • An electronic, aptamer-based small-molecule sensor for the rapid, label-free detection of cocaine in adulterated samples and biological fluids.
    J Am Chem Soc, Vol. 128, No. 10. (15 March 2006), pp. 3138-3139.
    by BR Baker, RY Lai, MS Wood, EH Doctor, AJ Heeger, KW Plaxco
    posted to aptamer small-molecule by kengg on 2007-09-24 16:28:57 as ** along with 1 person shuns
  • Peptide aptamers as guides for small-molecule drug discovery.
    Drug Discov Today, Vol. 11, No. 7-8. (April 2006), pp. 334-341.
    by IC Baines, P Colas
    posted to aptamer peptide review small-molecule by kengg on 2007-09-24 16:18:36 as **
  • A modular and extensible RNA-based gene-regulatory platform for engineering cellular function
    PNAS (20 August 2007), 0703961104.
    by Maung N Win, Christina D Smolke
    posted to aptamer small-molecule by kengg on 2007-09-24 15:58:05 as read along with 4 people and 2 groups austin dchughes zwang Jporci G4ID Genetics-of-Gambling
  • Systems chemical biology
    Nat Chem Biol, Vol. 3, No. 8. (2007), pp. 447-450.
    by Tudor Oprea, Alexander Tropsha, Jean-Loup Faulon, Mark D Rintoul
    posted to review small-molecule by kengg on 2007-09-17 19:01:35 as ** along with 1 person and 1 group jyuh Plantandetc
  • Medicinal Plants and Phytomedicines. Linking Plant Biochemistry and Physiology to Human Health
    Plant Physiol., Vol. 124, No. 2. (1 October 2000), pp. 507-514.
    by Donald P Briskin
    posted to metabolite small-molecule by kengg on 2007-09-17 16:07:31 as ** along with 1 group Plantandetc
  • Identification of antibiotic clarithromycin binding peptide displayed by T7 phage particles.
    J Antibiot (Tokyo), Vol. 59, No. 10. (October 2006), pp. 625-632.
    by T Morimura, N Noda, Y Kato, T Watanabe, T Saitoh, T Yamazaki, K Takada, S Aoki, K Ohta, M Ohshige, K Sakaguchi, F Sugawara
    posted to phage small-molecule by kengg on 2007-09-13 20:07:06 as ** along with 1 group Plantandetc
  • A bridge between chemistry and biology
    Nat Chem Biol, Vol. 2, No. 8. (2006), pp. 392-394.
    by Kazuya Kikuchi, Hideaki Kakeya
    posted to phage review small-molecule by kengg on 2007-09-12 14:35:40 as ** along with 1 group Plantandetc
  • Novel peptide sequence ("IQ-tag") with high affinity for NIR fluorochromes allows protein and cell specific labeling for in vivo imaging.
    PLoS ONE, Vol. 2 (2007)
    by KA Kelly, J Carson, JR McCarthy, R Weissleder
    posted to small-molecule by kengg on 2007-08-14 19:36:27 as ** along with 1 group Plantandetc
  • Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
    Nature, Vol. 401, No. 6749. (1999), pp. 188-193.
    by Michael S Finnin, Jill R Donigian, Alona Cohen, Victoria M Richon, Richard A Rifkind, Paul A Marks, Ronald Breslow, Nikola P Pavletich
    posted to acetylation epigenetics histone small-molecule by kengg on 2007-08-10 15:44:55 as ** along with 1 group Plantandetc
  • Sequence-Selective DNA Recognition: Natural Products and Nature's Lessons
    Chemistry & Biology, Vol. 11, No. 12. (December 2004), pp. 1607-1617.
    by Winston C Tse, Dale L Boger
    posted to review small-molecule by kengg on 2007-08-07 10:56:22 as ** along with 1 group Plantandetc
  • Target identification in chemical genetics: the (often) missing link.
    Chem Biol, Vol. 11, No. 5. (May 2004), pp. 593-597.
    by L Burdine, T Kodadek
    posted to review small-molecule by kengg on 2007-08-07 10:35:48 as ** along with 1 group Plantandetc
  • Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.
    Proc Natl Acad Sci U S A, Vol. 98, No. 1. (2 January 2001), pp. 87-92.
    by R Furumai, Y Komatsu, N Nishino, S Khochbin, M Yoshida, S Horinouchi
    posted to acetylation histone small-molecule by kengg on 2007-08-07 10:33:21 as ** along with 1 group Plantandetc
  • Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.
    Chem Biol, Vol. 14, No. 6. (June 2007), pp. 645-657.
    by K Mantelingu, BA Reddy, V Swaminathan, AH Kishore, NB Siddappa, GV Kumar, G Nagashankar, N Natesh, S Roy, PP Sadhale, U Ranga, C Narayana, TK Kundu
    posted to acetylation histone small-molecule by kengg on 2007-08-07 10:25:23 as ** along with 1 group Plantandetc
  • Analysis of RNA-protein interactions by a microplate-based fluorescence anisotropy assay.
    Anal Biochem, Vol. 350, No. 2. (15 March 2006), pp. 222-232.
    by C Mao, KG Flavin, S Wang, R Dodson, J Ross, DJ Shapiro
    posted to chromatin small-molecule by kengg on 2007-08-07 10:17:13 as ** along with 1 group Plantandetc
  • A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
    Science, Vol. 272, No. 5260. (19 April 1996), pp. 408-411.
    by J Taunton, CA Hassig, SL Schreiber
    posted to epigenetics histone small-molecule by kengg on 2007-08-06 10:32:34 as ** along with 1 group Plantandetc
  • Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.
    J Biol Chem, Vol. 265, No. 28. (5 October 1990), pp. 17174-17179.
    by M Yoshida, M Kijima, M Akita, T Beppu
    posted to epigenetics small-molecule by kengg on 2007-08-06 10:24:19 as ** along with 1 group Plantandetc
  • Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide
    PNAS, Vol. 96, No. 10. (11 May 1999), pp. 5645-5650.
    by Cynthia A Byrd, William Bornmann, Hediye Erdjument-Bromage, Paul Tempst, Nikola Pavletich, Neal Rosen, Carl F Nathan, Aihao Ding
    posted to small-molecule by kengg on 2007-07-10 09:32:49 as ** along with 1 group Plantandetc
  • Altered maturation of dendritic cells by taxol, an anticancer drug.
    J Vet Sci, Vol. 4, No. 3. (December 2003), pp. 229-234.
    by HG Joo
    posted to small-molecule by kengg on 2007-07-09 11:00:50 as ** along with 1 group Plantandetc
  • FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast.
    Mol Microbiol, Vol. 37, No. 6. (September 2000), pp. 1480-1493.
    by J Kunz, A Loeschmann, M Deuter-Reinhard, MN Hall
    posted to small-molecule by kengg on 2007-07-09 10:18:35 as ** along with 1 group Plantandetc
  • Genomic signatures to guide the use of chemotherapeutics.
    Nat Med (22 October 2006)
    by Anil Potti, Holly K K Dressman, Andrea Bild, Richard F F Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, Hope Cottrill, Michael J J Kelley, Rebecca Petersen, David Harpole, Jeffrey Marks, Andrew Berchuck, Geoffrey S S Ginsburg, Phillip Febbo, Johnathan Lancaster, Joseph R R Nevins
    posted to microarray small-molecule by kengg on 2007-04-19 17:09:40 as ** along with 5 people and 3 groups jfr jyuh giovanni frohike mgaldzic GeschwindLab CHIP Plantandetc
  • Bypassing a kinase activity with an ATP-competitive drug.
    Science, Vol. 302, No. 5650. (28 November 2003), pp. 1533-1537.
    by FR Papa, C Zhang, K Shokat, P Walter
    posted to small-molecule by kengg on 2007-02-28 16:53:04 as ** along with 1 group Plantandetc
  • Chemical Genetics: Where Genetics and Pharmacology Meet
    Cell, Vol. 128, No. 3. (9 February 2007), pp. 425-430.
    by Zachary A Knight, Kevan M Shokat
    posted to review small-molecule by kengg on 2007-02-28 16:24:13 as ** along with 2 people and 1 group alexg Seongmin Plantandetc
  • Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage.
    Science, Vol. 280, No. 5366. (15 May 1998), pp. 1066-1069.
    by XC Le, JZ Xing, J Lee, SA Leadon, M Weinfeld
    posted to capillary small-molecule by kengg on 2007-02-23 18:49:59 as ** along with 1 group Plantandetc
  • Studies of protein--DNA interactions by capillary electrophoresis/laser-induced fluorescence polarization.
    Anal Chem, Vol. 72, No. 22. (15 November 2000), pp. 5583-5589.
    by QH Wan, XC Le
    posted to capillary small-molecule by kengg on 2007-02-23 18:31:12 as ** along with 1 group Plantandetc
  • Fluorescence polarization studies of affinity interactions in capillary electrophoresis.
    Anal Chem, Vol. 71, No. 19. (1 October 1999), pp. 4183-4189.
    by QH Wan, XC Le
    posted to capillary small-molecule by kengg on 2007-02-23 18:30:05 as ** along with 1 group Plantandetc
  • The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
    Science, Vol. 313, No. 5795. (29 September 2006), pp. 1929-1935.
    by J Lamb, ED Crawford, D Peck, JW Modell, IC Blat, MJ Wrobel, J Lerner, JP Brunet, A Subramanian, KN Ross, M Reich, H Hieronymus, G Wei, SA Armstrong, SJ Haggarty, PA Clemons, R Wei, SA Carr, ES Lander, TR Golub
    posted to tfs small-molecule network bioinformatics by kengg on 2007-01-09 14:15:01 as ** along with 21 people and 9 groups askrajiv BragilMassoud jyuh kuhn jfr yas balajis marcius lhonigberg neveaire ealloza koller mlovell jdiggans ezra jeremymiller frohike massivemayhem lp2 pablomendes jdiezperezj Biostatistics Computational-Genomics Bioinformatics Neuroscience T_lab BioinfoCIPF SGU-CIPF GeschwindLab Plantandetc
  • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.
    Science, Vol. 253, No. 5022. (23 August 1991), pp. 905-909.
    by J Heitman, NR Movva, MN Hall
    posted to small-molecule by kengg on 2006-11-16 21:35:53 as ** along with 2 people and 1 group adiel jjohnson17 Plantandetc
  • FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.
    Proc Natl Acad Sci U S A, Vol. 88, No. 5. (1 March 1991), pp. 1948-1952.
    by J Heitman, NR Movva, PC Hiestand, MN Hall
    posted to small-molecule by kengg on 2006-11-16 21:35:39 as ** along with 1 person and 1 group adiel Plantandetc
  • Small molecule modulators of transcription.
    Angew Chem Int Ed Engl, Vol. 45, No. 28. (10 July 2006), pp. 4552-4560.
    by HD Arndt
    posted to review small-molecule tfs by kengg on 2006-11-09 02:16:42 as ** along with 1 group Plantandetc
  • Approaches to the description and prediction of the binding affinity of small-molecule ligands to macromolecular receptors.
    Angew Chem Int Ed Engl, Vol. 41, No. 15. (2 August 2002), pp. 2644-2676.
    by H Gohlke, G Klebe
    posted to review small-molecule by kengg on 2006-11-09 02:10:53 as ** along with 1 person and 1 group lillekatt Plantandetc
  • Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly.
    Curr Opin Chem Biol, Vol. 8, No. 4. (August 2004), pp. 399-406.
    by DA Erlanson, SK Hansen
    posted to review small-molecule by kengg on 2006-11-03 02:26:23 as ** along with 2 people and 3 groups mdimmic sangeetha Bioinformatics insilicodrug Plantandetc
  • A high-throughput phage display screening method using a combination of real-time PCR and affinity chromatography.
    Comb Chem High Throughput Screen, Vol. 9, No. 1. (January 2006), pp. 55-61.
    by K Morohashi, T Arai, S Saito, M Watanabe, K Sakaguchi, F Sugawara
    posted to phage small-molecule by kengg on 2006-11-03 02:17:21 as ** along with 1 group Plantandetc
  • Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
    Cell, Vol. 127, No. 2. (20 October 2006), pp. 341-353.
    by Yongna Xing, Yanhui Xu, Yu Chen, Philip D Jeffrey, Yang Chao, Zheng Lin, Zhu Li, Stefan Strack, Jeffry B Stock, Yigong Shi
    posted to small-molecule structure by kengg on 2006-10-21 14:22:37 as ** along with 1 group Plantandetc
  • Identification of a drug target motif: an anti-tumor drug NK109 interacts with a PNxxxxP.
    Biochem Pharmacol, Vol. 70, No. 1. (1 July 2005), pp. 37-46.
    by K Morohashi, A Yoshino, A Yoshimori, S Saito, S Tanuma, K Sakaguchi, F Sugawara
    posted to phage small-molecule by kengg on 2006-10-12 20:49:01 as ** along with 1 group Plantandetc
  • A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules
    Cell, Vol. 126, No. 5. (8 September 2006), pp. 995-1004.
    by Laura A Banaszynski, Ling-Chun Chen, Lystranne A Maynard-Smith, Lisa AG Ooi, Thomas J Wandless
    posted to small-molecule by kengg on 2006-09-08 14:41:00 as ** along with 5 people and 2 groups jyuh manduca brant johncumbers lechristophe EisenLab Plantandetc
  • SPR imaging of photo-cross-linked small-molecule arrays on gold.
    Anal Chem, Vol. 78, No. 7. (1 April 2006), pp. 2226-2230.
    by N Kanoh, M Kyo, K Inamori, A Ando, A Asami, A Nakao, H Osada
    posted to small-molecule by kengg on 2006-08-27 02:58:36 as ** along with 1 group Plantandetc
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