Suppression of aging in mice by the hormone Klotho.

by: H Kurosu, M Yamamoto, JD Clark, JV Pastor, A Nandi, P Gurnani, OP McGuinness, H Chikuda, M Yamaguchi, H Kawaguchi, I Shimomura, Y Takayama, J Herz, CR Kahn, KP Rosenblatt, M Kuro-o

Science, Vol. 309, No. 5742. (16 September 2005), pp. 1829-1833.

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摘要

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.

@article{citeulike:456070, abstract = {A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.}, address = {Department of Pathology, University of Texas (UT) Southwestern Medical Center at Dallas, 5323 Harry Hines Bouleuvard, Dallas, TX 75390-9072, USA.}, author = {Kurosu, H. and Yamamoto, M. and Clark, J. D. and Pastor, J. V. and Nandi, A. and Gurnani, P. and McGuinness, O. P. and Chikuda, H. and Yamaguchi, M. and Kawaguchi, H. and Shimomura, I. and Takayama, Y. and Herz, J. and Kahn, C. R. and Rosenblatt, K. P. and Kuro-o, M. }, citeulike-article-id = {456070}, doi = {http://dx.doi.org/10.1126/science.1112766}, issn = {1095-9203}, journal = {Science}, keywords = {aging, klotho, mouse}, month = {September}, number = {5742}, pages = {1829--1833}, posted-at = {2008-06-02 02:58:47}, priority = {2}, title = {Suppression of aging in mice by the hormone Klotho.}, url = {http://dx.doi.org/10.1126/science.1112766}, volume = {309}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:456070 L3 - citeulike-article-id:456070 TI - Suppression of aging in mice by the hormone Klotho. JF - Science VL - 309 IS - 5742 SP - 1829 EP - 1833 AD - Department of Pathology, University of Texas (UT) Southwestern Medical Center at Dallas, 5323 Harry Hines Bouleuvard, Dallas, TX 75390-9072, USA. SN - 1095-9203 N2 - A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals. KW - aging KW - klotho KW - mouse AU - Kurosu, H AU - Yamamoto, M AU - Clark, JD AU - Pastor, JV AU - Nandi, A AU - Gurnani, P AU - McGuinness, OP AU - Chikuda, H AU - Yamaguchi, M AU - Kawaguchi, H AU - Shimomura, I AU - Takayama, Y AU - Herz, J AU - Kahn, CR AU - Rosenblatt, KP AU - Kuro-o, M PY - 2005/09/16/ UR - http://dx.doi.org/10.1126/science.1112766 ER -

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