An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.

@article{citeulike:3006115, abstract = {The human chromosome 7p21 locus harbors a major gene that influences variation of glomerular filtration rate and development of end-stage renal disease. The pro-inflammatory IL-6 cytokine is a candidate gene since chronic inflammation has been implicated in diabetic nephropathy and this gene is located under the peak of linkage. To test this, single nucleotide polymorphism (SNP) and haplotype analyses were performed using a case-control study of 295 patients consisting of 138 with proteinuria, 157 with chronic renal failure and these were compared to174 control patients with normal albumin excretion. Five tagging SNPs were selected for analysis based on linkage disequilibrium patterns and proximity to the functionally important -634G>C SNP in the IL-6 promoter. Initial analysis suggested that a -174G>C polymorphism may be associated with risk of chronic renal failure but this was not significant after Bonferroni correction. While haplotype analyses showed no association with proteinuria; a significant association with chronic renal failure was found. There was significantly more of the GGGAGC haplotype among patients with chronic renal failure compared to controls and this association remained significant even after correction for multiple testing. Our study has found a specific IL-6 haplotype conferring risk for impaired renal function in patients with type 2 diabetes.Kidney International advance online publication, 21 May 2008; doi:10.1038/ki.2008.202.}, address = {1Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine,National University of Singapore, Singapore, Singapore.}, author = {Ng, Daniel Pk P. and Nurbaya, Siti and Ye, Sandra Hj H. and Krolewski, Andrzej S S. }, citeulike-article-id = {3006115}, doi = {10.1038/ki.2008.202}, issn = {1523-1755}, journal = {Kidney international}, keywords = {dn, il6, snp}, month = {May}, posted-at = {2008-07-15 16:42:40}, priority = {2}, title = {An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.}, url = {http://dx.doi.org/10.1038/ki.2008.202}, year = {2008} }

TY - JOUR ID - citeulike:3006115 L3 - citeulike-article-id:3006115 TI - An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients. JF - Kidney international AD - 1Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine,National University of Singapore, Singapore, Singapore. SN - 1523-1755 N2 - The human chromosome 7p21 locus harbors a major gene that influences variation of glomerular filtration rate and development of end-stage renal disease. The pro-inflammatory IL-6 cytokine is a candidate gene since chronic inflammation has been implicated in diabetic nephropathy and this gene is located under the peak of linkage. To test this, single nucleotide polymorphism (SNP) and haplotype analyses were performed using a case-control study of 295 patients consisting of 138 with proteinuria, 157 with chronic renal failure and these were compared to174 control patients with normal albumin excretion. Five tagging SNPs were selected for analysis based on linkage disequilibrium patterns and proximity to the functionally important -634G>C SNP in the IL-6 promoter. Initial analysis suggested that a -174G>C polymorphism may be associated with risk of chronic renal failure but this was not significant after Bonferroni correction. While haplotype analyses showed no association with proteinuria; a significant association with chronic renal failure was found. There was significantly more of the GGGAGC haplotype among patients with chronic renal failure compared to controls and this association remained significant even after correction for multiple testing. Our study has found a specific IL-6 haplotype conferring risk for impaired renal function in patients with type 2 diabetes.Kidney International advance online publication, 21 May 2008; doi:10.1038/ki.2008.202. KW - dn KW - il6 KW - snp AU - Ng, Daniel Pk AU - Nurbaya, Siti AU - Ye, Sandra Hj AU - Krolewski, Andrzej S PY - 2008/05/21/ UR - http://dx.doi.org/10.1038/ki.2008.202 ER -