Cachexia: pathophysiology and clinical relevance.

by: JE Morley, DR Thomas, MM Wilson

The American journal of clinical nutrition, Vol. 83, No. 4. (April 2006), pp. 735-743.

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摘要

Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration. The pathophysiology of cachexia is reviewed in this article. The major cause appears to be cytokine excess. Other potential mediators include testosterone and insulin-like growth factor I deficiency, excess myostatin, and excess glucocorticoids. Numerous diseases can result in cachexia, each by a slightly different mechanism. Both nutritional support and orexigenic agents play a role in the management of cachexia.

@article{citeulike:2940594, abstract = {Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration. The pathophysiology of cachexia is reviewed in this article. The major cause appears to be cytokine excess. Other potential mediators include testosterone and insulin-like growth factor I deficiency, excess myostatin, and excess glucocorticoids. Numerous diseases can result in cachexia, each by a slightly different mechanism. Both nutritional support and orexigenic agents play a role in the management of cachexia.}, address = {Division of Geriatric Medicine, Saint Louis University School of Medicine, 1042 South Grand Boulevard M238, St Louis, MO 63104, USA. morley@slu.edu}, author = {Morley, J. E. and Thomas, D. R. and Wilson, M. M. }, citeulike-article-id = {2940594}, issn = {0002-9165}, journal = {The American journal of clinical nutrition}, keywords = {cachexia}, month = {April}, number = {4}, pages = {735--743}, posted-at = {2008-06-29 01:50:36}, priority = {2}, title = {Cachexia: pathophysiology and clinical relevance.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/16600922}, volume = {83}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:2940594 L3 - citeulike-article-id:2940594 TI - Cachexia: pathophysiology and clinical relevance. JF - The American journal of clinical nutrition VL - 83 IS - 4 SP - 735 EP - 743 AD - Division of Geriatric Medicine, Saint Louis University School of Medicine, 1042 South Grand Boulevard M238, St Louis, MO 63104, USA. morley@slu.edu SN - 0002-9165 N2 - Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration. The pathophysiology of cachexia is reviewed in this article. The major cause appears to be cytokine excess. Other potential mediators include testosterone and insulin-like growth factor I deficiency, excess myostatin, and excess glucocorticoids. Numerous diseases can result in cachexia, each by a slightly different mechanism. Both nutritional support and orexigenic agents play a role in the management of cachexia. KW - cachexia AU - Morley, JE AU - Thomas, DR AU - Wilson, MM PY - 2006/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/16600922 ER -

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