Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001 to 2004

@article{citeulike:2901016, abstract = {Objective-- The purpose of this study was to determine the association between 25-hydroxyvitamin D (25(OH)D) levels and the prevalence of peripheral arterial disease (PAD) in the general United States population. Methods and Results-- We analyzed data from 4839 participants of the National Health and Nutrition Examination Survey 2001 to 2004 to evaluate the relationship between 25(OH)D and PAD (defined as an ankle-brachial index <0.9). Across quartiles of 25(OH)D, from lowest to highest, the prevalence of PAD was 8.1\%, 5.4\%, 4.9\%, and 3.7\% (P trend <0.001). After multivariable adjustment for demographics, comorbidities, physical activity level, and laboratory measures, the prevalence ratio of PAD for the lowest, compared to the highest, 25(OH)D quartile (<17.8 and [\&ge;]29.2 ng/mL, respectively) was 1.80 (95\% confidence interval: 1.19, 2.74). For each 10 ng/mL lower 25(OH)D level, the multivariable-adjusted prevalence ratio of PAD was 1.35 (95\% confidence interval: 1.15, 1.59). Conclusions-- Low serum 25(OH)D levels are associated with a higher prevalence of PAD. Several mechanisms have been invoked in the literature to support a potential antiatherosclerotic activity of vitamin D. Prospective cohort and mechanistic studies should be designed to confirm this association. Vitamin D is an inhibitor of the renin-angiotensin system and has antiinflammatory and anticoagulant properties. Among 4839 NHANES 2001 to 2004 participants, low 25(OH)D levels were associated with a higher prevalence of PAD, after multivariate adjustment. To confirm this association, longitudinal cohort and mechanistic studies are needed. 10.1161/ATVBAHA.108.165886}, author = {Melamed, Michal L. and Muntner, Paul and Michos, Erin D. and Uribarri, Jaime and Weber, Collin and Sharma, Jyotirmay and Raggi, Paolo }, citeulike-article-id = {2901016}, doi = {10.1161/ATVBAHA.108.165886}, journal = {Arterioscler Thromb Vasc Biol}, keywords = {cv, vitamin-d}, month = {June}, number = {6}, pages = {1179--1185}, posted-at = {2008-06-17 04:37:25}, priority = {2}, title = {Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001 to 2004}, url = {http://dx.doi.org/10.1161/ATVBAHA.108.165886}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:2901016 L3 - citeulike-article-id:2901016 TI - Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001 to 2004 JF - Arterioscler Thromb Vasc Biol VL - 28 IS - 6 SP - 1179 EP - 1185 N2 - Objective-- The purpose of this study was to determine the association between 25-hydroxyvitamin D (25(OH)D) levels and the prevalence of peripheral arterial disease (PAD) in the general United States population. Methods and Results-- We analyzed data from 4839 participants of the National Health and Nutrition Examination Survey 2001 to 2004 to evaluate the relationship between 25(OH)D and PAD (defined as an ankle-brachial index <0.9). Across quartiles of 25(OH)D, from lowest to highest, the prevalence of PAD was 8.1%, 5.4%, 4.9%, and 3.7% (P trend <0.001). After multivariable adjustment for demographics, comorbidities, physical activity level, and laboratory measures, the prevalence ratio of PAD for the lowest, compared to the highest, 25(OH)D quartile (<17.8 and [&ge;]29.2 ng/mL, respectively) was 1.80 (95% confidence interval: 1.19, 2.74). For each 10 ng/mL lower 25(OH)D level, the multivariable-adjusted prevalence ratio of PAD was 1.35 (95% confidence interval: 1.15, 1.59). Conclusions-- Low serum 25(OH)D levels are associated with a higher prevalence of PAD. Several mechanisms have been invoked in the literature to support a potential antiatherosclerotic activity of vitamin D. Prospective cohort and mechanistic studies should be designed to confirm this association. Vitamin D is an inhibitor of the renin-angiotensin system and has antiinflammatory and anticoagulant properties. Among 4839 NHANES 2001 to 2004 participants, low 25(OH)D levels were associated with a higher prevalence of PAD, after multivariate adjustment. To confirm this association, longitudinal cohort and mechanistic studies are needed. 10.1161/ATVBAHA.108.165886 KW - cv KW - vitamin-d AU - Melamed, Michal AU - Muntner, Paul AU - Michos, Erin AU - Uribarri, Jaime AU - Weber, Collin AU - Sharma, Jyotirmay AU - Raggi, Paolo PY - 2008/06/01/ UR - http://dx.doi.org/10.1161/ATVBAHA.108.165886 ER -