A modified Cockcroft-Gault formula taking into account the body surface area gives a more accurate estimation of the glomerular filtration rate.

@article{citeulike:2663152, abstract = {We sought to validate the improvement by adjustment for body surface area (BSA) of the accuracy of the original Cockcroft-Gault equation to estimate glomerular filtration rate (GFR), in a prospective cross-sectional study of 269 European patients with chronic kidney disease (CKD). We compared 3 methods: original Cockcroft-Gault equation, modified Cockcroft-Gault formula adjusted for BSA and abbreviated Modification of Diet in Renal Disease (MDRD) equation, using inulin clearance. Statistical analyses comprised repeated-measures analysis of variance (ANOVA), determination of the Pearson coefficient of correlation and a Bland-Altman concordance study. The ability of the GFR estimates to properly categorize patients in K/DOQI stages of CKD was also examined. Inulin clearance differed significantly from the standard Cockcroft-Gault method (ANOVA, p<0.001) and the abbreviated MDRD method (ANOVA, p<0.001) but not from the BSA-modified Cockcroft-Gault formula. Inulin clearance correlated better with the BSA-modified Cockcroft-Gault formula (r=0.88) and abbreviated MDRD equation (r=0.87) than with the standard Cockcroft-Gault equation (r=0.82). In concordance studies, bias was far smaller with the BSA-modified Cockcroft-Gault formula (mean bias -1.75 ml/min), than with the standard Cockcroft-Gault equation (mean bias -4.72 ml/min). The bias of the abbreviated MDRD was larger (mean bias +6.24 ml/min). Only patients with CKD stage 1 were better categorized with the BSA-modified Cockcroft-Gault formula and with the standard Cockcroft-Gault estimate than with the abbreviated MDRD equation. We conclude that adjustment for body surface area improves accuracy of the original Cockcroft-Gault equation.}, address = {Unit of Nephrology and Dialysis, Centre Hospitalier Priv\'{e} Claude Galien, Quincy sous Senart - France. rostotom@easynet.fr}, author = {Rostoker, G. and Andrivet, P. and Pham, I. and Griuncelli, M. and Adnot, S. }, citeulike-article-id = {2663152}, issn = {1121-8428}, journal = {Journal of nephrology}, keywords = {gfr, method}, number = {5}, pages = {576--585}, posted-at = {2008-04-13 09:53:06}, priority = {2}, title = {A modified Cockcroft-Gault formula taking into account the body surface area gives a more accurate estimation of the glomerular filtration rate.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17918143}, volume = {20}, year = {2007} }

TY - JOUR ID - citeulike:2663152 L3 - citeulike-article-id:2663152 TI - A modified Cockcroft-Gault formula taking into account the body surface area gives a more accurate estimation of the glomerular filtration rate. JF - Journal of nephrology VL - 20 IS - 5 SP - 576 EP - 585 AD - Unit of Nephrology and Dialysis, Centre Hospitalier Privé Claude Galien, Quincy sous Senart - France. rostotom@easynet.fr SN - 1121-8428 N2 - We sought to validate the improvement by adjustment for body surface area (BSA) of the accuracy of the original Cockcroft-Gault equation to estimate glomerular filtration rate (GFR), in a prospective cross-sectional study of 269 European patients with chronic kidney disease (CKD). We compared 3 methods: original Cockcroft-Gault equation, modified Cockcroft-Gault formula adjusted for BSA and abbreviated Modification of Diet in Renal Disease (MDRD) equation, using inulin clearance. Statistical analyses comprised repeated-measures analysis of variance (ANOVA), determination of the Pearson coefficient of correlation and a Bland-Altman concordance study. The ability of the GFR estimates to properly categorize patients in K/DOQI stages of CKD was also examined. Inulin clearance differed significantly from the standard Cockcroft-Gault method (ANOVA, p<0.001) and the abbreviated MDRD method (ANOVA, p<0.001) but not from the BSA-modified Cockcroft-Gault formula. Inulin clearance correlated better with the BSA-modified Cockcroft-Gault formula (r=0.88) and abbreviated MDRD equation (r=0.87) than with the standard Cockcroft-Gault equation (r=0.82). In concordance studies, bias was far smaller with the BSA-modified Cockcroft-Gault formula (mean bias -1.75 ml/min), than with the standard Cockcroft-Gault equation (mean bias -4.72 ml/min). The bias of the abbreviated MDRD was larger (mean bias +6.24 ml/min). Only patients with CKD stage 1 were better categorized with the BSA-modified Cockcroft-Gault formula and with the standard Cockcroft-Gault estimate than with the abbreviated MDRD equation. We conclude that adjustment for body surface area improves accuracy of the original Cockcroft-Gault equation. KW - gfr KW - method AU - Rostoker, G AU - Andrivet, P AU - Pham, I AU - Griuncelli, M AU - Adnot, S PY - 2007///t UR - http://view.ncbi.nlm.nih.gov/pubmed/17918143 ER -