A possible link between resveratrol and TGF-beta: Resveratrol induction of TGF-beta expression and signaling.

by: Fumiko Suenaga, Kyosuke Hatsushika, Shinichi Takano, Takashi Ando, Yuko Ohnuma, Hideoki Ogawa, Atsuhito Nakao

FEBS Lett (30 January 2008)

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摘要

Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-beta. This study reports that resveratrol increased transcription of the TGF-beta2 gene, enhanced the production of TGF-beta2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-beta expression and signaling.

@article{citeulike:2359863, abstract = {Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-beta. This study reports that resveratrol increased transcription of the TGF-beta2 gene, enhanced the production of TGF-beta2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-beta expression and signaling.}, address = {Department of Immunology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.}, author = {Suenaga, Fumiko and Hatsushika, Kyosuke and Takano, Shinichi and Ando, Takashi and Ohnuma, Yuko and Ogawa, Hideoki and Nakao, Atsuhito }, citeulike-article-id = {2359863}, doi = {10.1016/j.febslet.2008.01.024}, issn = {0014-5793}, journal = {FEBS Lett}, month = {January}, posted-at = {2008-02-10 15:48:32}, priority = {2}, title = {A possible link between resveratrol and TGF-beta: Resveratrol induction of TGF-beta expression and signaling.}, url = {http://dx.doi.org/10.1016/j.febslet.2008.01.024}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2359863 L3 - citeulike-article-id:2359863 TI - A possible link between resveratrol and TGF-beta: Resveratrol induction of TGF-beta expression and signaling. JF - FEBS Lett AD - Department of Immunology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan. SN - 0014-5793 N2 - Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-beta. This study reports that resveratrol increased transcription of the TGF-beta2 gene, enhanced the production of TGF-beta2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-beta expression and signaling. AU - Suenaga, Fumiko AU - Hatsushika, Kyosuke AU - Takano, Shinichi AU - Ando, Takashi AU - Ohnuma, Yuko AU - Ogawa, Hideoki AU - Nakao, Atsuhito PY - 2008/01/30/ UR - http://dx.doi.org/10.1016/j.febslet.2008.01.024 ER -

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