Mass spectrometry-based "omics" technologies in cancer diagnostics.

by: X Zhang, D Wei, Y Yap, L Li, S Guo, F Chen

Mass Spectrom Rev, Vol. 26, No. 3. (n 2007), pp. 403-431.

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摘要

Many "omics" techniques have been developed for one goal: biomarker discovery and early diagnosis of human cancers. A comprehensive review of mass spectrometry-based "omics" approaches performed on various biological samples for molecular diagnosis of human cancers is presented in this article. Furthermore, the existing and potential problems/solutions (both de facto experimental and bioinformatic challenges), and future prospects have been extensively discussed. Although the use of present omic methods as diagnostic tools are still in their infant stage and consequently not ready for immediate clinical use, it can be envisaged that the "omics"-based cancer diagnostics will gradually enter into the clinic in next 10 years as an important supplement to current clinical diagnostics.

@article{citeulike:2184190, abstract = {Many "omics" techniques have been developed for one goal: biomarker discovery and early diagnosis of human cancers. A comprehensive review of mass spectrometry-based "omics" approaches performed on various biological samples for molecular diagnosis of human cancers is presented in this article. Furthermore, the existing and potential problems/solutions (both de facto experimental and bioinformatic challenges), and future prospects have been extensively discussed. Although the use of present omic methods as diagnostic tools are still in their infant stage and consequently not ready for immediate clinical use, it can be envisaged that the "omics"-based cancer diagnostics will gradually enter into the clinic in next 10 years as an important supplement to current clinical diagnostics.}, address = {College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China. snow\_dance@sina.com}, author = {Zhang, X. and Wei, D. and Yap, Y. and Li, L. and Guo, S. and Chen, F. }, citeulike-article-id = {2184190}, doi = {10.1002/mas.20132}, issn = {0277-7037}, journal = {Mass Spectrom Rev}, number = {3}, pages = {403--431}, posted-at = {2008-01-01 03:12:16}, priority = {2}, title = {Mass spectrometry-based "omics" technologies in cancer diagnostics.}, url = {http://dx.doi.org/10.1002/mas.20132}, volume = {26}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:2184190 L3 - citeulike-article-id:2184190 TI - Mass spectrometry-based "omics" technologies in cancer diagnostics. JF - Mass Spectrom Rev VL - 26 IS - 3 SP - 403 EP - 431 AD - College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China. snow_dance@sina.com SN - 0277-7037 N2 - Many "omics" techniques have been developed for one goal: biomarker discovery and early diagnosis of human cancers. A comprehensive review of mass spectrometry-based "omics" approaches performed on various biological samples for molecular diagnosis of human cancers is presented in this article. Furthermore, the existing and potential problems/solutions (both de facto experimental and bioinformatic challenges), and future prospects have been extensively discussed. Although the use of present omic methods as diagnostic tools are still in their infant stage and consequently not ready for immediate clinical use, it can be envisaged that the "omics"-based cancer diagnostics will gradually enter into the clinic in next 10 years as an important supplement to current clinical diagnostics. AU - Zhang, X AU - Wei, D AU - Yap, Y AU - Li, L AU - Guo, S AU - Chen, F PY - 2007///n UR - http://dx.doi.org/10.1002/mas.20132 ER -

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