The STATs in cell stress-type responses.

by: Andrew C Dudley, David Thomas, James Best, Alicia Jenkins

Cell Commun Signal, Vol. 2, No. 1. (6 August 2004)

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摘要

In the early 1990's, a new cell signaling pathway was described. This new paradigm, now known as the JAK/STAT pathway, has been extensively investigated in immune-type cells in response to interferons and interleukins. However, recent evidence suggests that the JAK/STAT pathway also mediates diverse cellular responses to various forms of biological stress including hypoxia/reperfusion, endotoxin, ultraviolet light, and hyperosmolarity. The current literature describing the JAK/STAT pathway's role in cellular stress responses has been reviewed herein, but it is clear that our knowledge in this area is far from complete.

@article{citeulike:1937133, abstract = {In the early 1990's, a new cell signaling pathway was described. This new paradigm, now known as the JAK/STAT pathway, has been extensively investigated in immune-type cells in response to interferons and interleukins. However, recent evidence suggests that the JAK/STAT pathway also mediates diverse cellular responses to various forms of biological stress including hypoxia/reperfusion, endotoxin, ultraviolet light, and hyperosmolarity. The current literature describing the JAK/STAT pathway's role in cellular stress responses has been reviewed herein, but it is clear that our knowledge in this area is far from complete.}, address = {The Department of Medicine, St, Vincent's Hospital, The University of Melbourne, Melbourne, Australia. drew@medstv.unimelb.edu.au}, author = {Dudley, Andrew C. and Thomas, David and Best, James and Jenkins, Alicia }, citeulike-article-id = {1937133}, doi = {10.1186/1478-811X-2-8}, issn = {1478-811X}, journal = {Cell Commun Signal}, month = {August}, number = {1}, posted-at = {2007-11-19 09:31:48}, priority = {2}, title = {The STATs in cell stress-type responses.}, url = {http://dx.doi.org/10.1186/1478-811X-2-8}, volume = {2}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:1937133 L3 - citeulike-article-id:1937133 TI - The STATs in cell stress-type responses. JF - Cell Commun Signal VL - 2 IS - 1 AD - The Department of Medicine, St, Vincent's Hospital, The University of Melbourne, Melbourne, Australia. drew@medstv.unimelb.edu.au SN - 1478-811X N2 - In the early 1990's, a new cell signaling pathway was described. This new paradigm, now known as the JAK/STAT pathway, has been extensively investigated in immune-type cells in response to interferons and interleukins. However, recent evidence suggests that the JAK/STAT pathway also mediates diverse cellular responses to various forms of biological stress including hypoxia/reperfusion, endotoxin, ultraviolet light, and hyperosmolarity. The current literature describing the JAK/STAT pathway's role in cellular stress responses has been reviewed herein, but it is clear that our knowledge in this area is far from complete. AU - Dudley, Andrew AU - Thomas, David AU - Best, James AU - Jenkins, Alicia PY - 2004/08/06/ UR - http://dx.doi.org/10.1186/1478-811X-2-8 ER -

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