Evolvability and hierarchy in rewired bacterial gene networks

by: Mark Isalan, Caroline Lemerle, Konstantinos Michalodimitrakis, Carsten Horn, Pedro Beltrao, Emanuele Raineri, Mireia Garriga-Canut, Luis Serrano

Nature, Vol. 452, No. 7189. (17 April 2008), pp. 840-845.

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josedavid : 0 私人注释和 1 公开注释 @本条文献.

This is an experiment on the robustness of genetic regulatory networks: E. coli doesn't mind its GRN to be largely rewired. It is not clear, though, whether it is because of properties of the network itself, or because of the GRN is only the first layer of regulatory networks in a cell (several other networks: post-transcriptional regulation, proteosome regulation, environmental regulation)

josedavid (公开注释 ) - 2008-04-17 10:45:03

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@article{citeulike:2678830, author = {Isalan, Mark and Lemerle, Caroline and Michalodimitrakis, Konstantinos and Horn, Carsten and Beltrao, Pedro and Raineri, Emanuele and Garriga-Canut, Mireia and Serrano, Luis }, citeulike-article-id = {2678830}, comment = {This is an experiment on the robustness of genetic regulatory networks: E. coli doesn't mind its GRN to be largely rewired. It is not clear, though, whether it is because of properties of the network itself, or because of the GRN is only the first layer of regulatory networks in a cell (several other networks: post-transcriptional regulation, proteosome regulation, environmental regulation)}, doi = {10.1038/nature06847}, journal = {Nature}, keywords = {grn, theo-bio}, month = {April}, number = {7189}, pages = {840--845}, posted-at = {2008-04-17 10:45:03}, priority = {2}, publisher = {Nature Publishing Group}, title = {Evolvability and hierarchy in rewired bacterial gene networks}, url = {http://dx.doi.org/10.1038/nature06847}, volume = {452}, year = {2008} }

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TY - JOUR ID - citeulike:2678830 L3 - citeulike-article-id:2678830 TI - Evolvability and hierarchy in rewired bacterial gene networks JF - Nature VL - 452 IS - 7189 SP - 840 EP - 845 PB - Nature Publishing Group KW - grn KW - theo-bio N1 - This is an experiment on the robustness of genetic regulatory networks: E. coli doesn't mind its GRN to be largely rewired. It is not clear, though, whether it is because of properties of the network itself, or because of the GRN is only the first layer of regulatory networks in a cell (several other networks: post-transcriptional regulation, proteosome regulation, environmental regulation) AU - Isalan, Mark AU - Lemerle, Caroline AU - Michalodimitrakis, Konstantinos AU - Horn, Carsten AU - Beltrao, Pedro AU - Raineri, Emanuele AU - Garriga-Canut, Mireia AU - Serrano, Luis PY - 2008/04/17/ UR - http://dx.doi.org/10.1038/nature06847 ER -

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