Strategies for mapping and cloning quantitative trait genes in rodents.

by: J Flint, W Valdar, S Shifman, R Mott

Nat Rev Genet, Vol. 6, No. 4. (April 2005), pp. 271-286.

View FullText article

DOI, Pubmed, Hubmed

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

jo_davies, fisherp

Find related articles with these CiteULike tags

genes, no-tag, qtl

摘要

Over the past 15 years, more than 2,000 quantitative trait loci (QTLs) have been identified in crosses between inbred strains of mice and rats, but less than 1% have been characterized at a molecular level. However, new resources, such as chromosome substitution strains and the proposed Collaborative Cross, together with new analytical tools, including probabilistic ancestral haplotype reconstruction in outbred mice, Yin-Yang crosses and in silico analysis of sequence variants in many inbred strains, could make QTL cloning tractable. We review the potential of these strategies to identify genes that underlie QTLs in rodents.

@article{flint05, abstract = {Over the past 15 years, more than 2,000 quantitative trait loci (QTLs) have been identified in crosses between inbred strains of mice and rats, but less than 1\% have been characterized at a molecular level. However, new resources, such as chromosome substitution strains and the proposed Collaborative Cross, together with new analytical tools, including probabilistic ancestral haplotype reconstruction in outbred mice, Yin-Yang crosses and in silico analysis of sequence variants in many inbred strains, could make QTL cloning tractable. We review the potential of these strategies to identify genes that underlie QTLs in rodents.}, address = {Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom. jf@well.ox.ac.uk}, author = {Flint, J. and Valdar, W. and Shifman, S. and Mott, R. }, citeulike-article-id = {782716}, doi = {10.1038/nrg1576}, issn = {1471-0056}, journal = {Nat Rev Genet}, month = {April}, number = {4}, pages = {271--286}, posted-at = {2008-05-02 16:55:23}, priority = {2}, title = {Strategies for mapping and cloning quantitative trait genes in rodents.}, url = {http://dx.doi.org/10.1038/nrg1576}, volume = {6}, year = {2005} }

RIS record

TY - JOUR ID - flint05 L3 - citeulike-article-id:782716 TI - Strategies for mapping and cloning quantitative trait genes in rodents. JF - Nat Rev Genet VL - 6 IS - 4 SP - 271 EP - 286 AD - Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom. jf@well.ox.ac.uk SN - 1471-0056 N2 - Over the past 15 years, more than 2,000 quantitative trait loci (QTLs) have been identified in crosses between inbred strains of mice and rats, but less than 1% have been characterized at a molecular level. However, new resources, such as chromosome substitution strains and the proposed Collaborative Cross, together with new analytical tools, including probabilistic ancestral haplotype reconstruction in outbred mice, Yin-Yang crosses and in silico analysis of sequence variants in many inbred strains, could make QTL cloning tractable. We review the potential of these strategies to identify genes that underlie QTLs in rodents. AU - Flint, J AU - Valdar, W AU - Shifman, S AU - Mott, R PY - 2005/04// UR - http://dx.doi.org/10.1038/nrg1576 ER -

RIS BibTeX